| pubmed-article:19666005 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C0043342 | lld:lifeskim |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C1704448 | lld:lifeskim |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C1819944 | lld:lifeskim |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:19666005 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:19666005 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19666005 | pubmed:dateCreated | 2009-9-8 | lld:pubmed |
| pubmed-article:19666005 | pubmed:abstractText | Islet-1 is a LIM domain transcription factor involved in several processes of embryonic development. Xenopus Islet-1 (Xisl-1) has been shown to be crucial for proper heart development. Here we show that Xisl-1 and Xisl-2 are differentially expressed in the nervous system in Xenopus embryos. Knock-down of Xisl-1 by specific morpholino leads to severe developmental defects, including eye and heart failure. Staining with the neuronal markers N-tubulin and Xisl-1 itself reveals that the motor neurons and a group of ventral interneurons are lost in the Xisl-1 morphants. Terminal dUTP nick-end labeling (TUNEL) analysis shows that Xisl-1 morpholino injection induces extensive apoptosis in the ventral neural plate, which can be largely inhibited by the apoptosis inhibitor M50054. We also find that over-expression of Xisl-1 is able to promote cell proliferation and induce Xstat3 expression in the injected side, suggesting a potential role for Xisl-1 in the regulation of cell proliferation in co-operation with the Jak-Stat pathway. | lld:pubmed |
| pubmed-article:19666005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19666005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19666005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19666005 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19666005 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19666005 | pubmed:author | pubmed-author:VikPP | lld:pubmed |
| pubmed-article:19666005 | pubmed:author | pubmed-author:MaoBingyuB | lld:pubmed |
| pubmed-article:19666005 | pubmed:author | pubmed-author:ZhaoShuhuaS | lld:pubmed |
| pubmed-article:19666005 | pubmed:author | pubmed-author:LiJiejingJ | lld:pubmed |
| pubmed-article:19666005 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19666005 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:19666005 | pubmed:volume | 388 | lld:pubmed |
| pubmed-article:19666005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19666005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19666005 | pubmed:pagination | 506-10 | lld:pubmed |
| pubmed-article:19666005 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:meshHeading | pubmed-meshheading:19666005... | lld:pubmed |
| pubmed-article:19666005 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19666005 | pubmed:articleTitle | Islet-1 is required for ventral neuron survival in Xenopus. | lld:pubmed |
| pubmed-article:19666005 | pubmed:affiliation | CAS-Max Planck Junior Scientist Group, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. | lld:pubmed |
| pubmed-article:19666005 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19666005 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:100126604 | entrezgene:pubmed | pubmed-article:19666005 | lld:entrezgene |
| entrez-gene:100306962 | entrezgene:pubmed | pubmed-article:19666005 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19666005 | lld:entrezgene |
