| pubmed-article:19656404 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C0029882 | lld:lifeskim |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C0670896 | lld:lifeskim |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C2004454 | lld:lifeskim |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C1823491 | lld:lifeskim |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C1843476 | lld:lifeskim |
| pubmed-article:19656404 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:19656404 | pubmed:dateCreated | 2009-9-3 | lld:pubmed |
| pubmed-article:19656404 | pubmed:abstractText | Toll-like receptor (TLR) signalling is crucial for innate immune responses to infection. The involvement of TLRs in otitis media (OM), the most prevalent childhood disease in developed countries, has been implicated by studies in middle ear cell lines, by association studies of TLR-related gene polymorphisms, and by altered OM in mice bearing mutations in TLR genes. Activated TLRs signal via two alternative intracellular signaling molecules with differing effects; MyD88 (Myeloid differentiation primary response gene 88) inducing primarily interleukin expression and TRIF (Tir-domain-containing adaptor inducing interferon beta) mediating type I interferon (IFN) expression. We tested the hypothesis that TRIF and type I IFN signaling play a role in OM, using a murine model of OM induced by non-typeable Haemophilus influenzae (NTHi). The ME inflammatory response to NTHi was examined in wild-type (WT) and TRIF-/- mice by qPCR, gene microarray, histopathology and bacterial culture. | lld:pubmed |
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| pubmed-article:19656404 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19656404 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19656404 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19656404 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19656404 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19656404 | pubmed:issn | 1471-2172 | lld:pubmed |
| pubmed-article:19656404 | pubmed:author | pubmed-author:RyanAllen FAF | lld:pubmed |
| pubmed-article:19656404 | pubmed:author | pubmed-author:PakKwangK | lld:pubmed |
| pubmed-article:19656404 | pubmed:author | pubmed-author:WassermanStep... | lld:pubmed |
| pubmed-article:19656404 | pubmed:author | pubmed-author:LeichtleAnkeA | lld:pubmed |
| pubmed-article:19656404 | pubmed:author | pubmed-author:HernandezMich... | lld:pubmed |
| pubmed-article:19656404 | pubmed:author | pubmed-author:WebsterNichol... | lld:pubmed |
| pubmed-article:19656404 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19656404 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:19656404 | pubmed:owner | NLM | lld:pubmed |
