| pubmed-article:1965078 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0021400 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0442118 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0042210 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:1965078 | lifeskim:mentions | umls-concept:C0008357 | lld:lifeskim |
| pubmed-article:1965078 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:1965078 | pubmed:dateCreated | 1991-5-23 | lld:pubmed |
| pubmed-article:1965078 | pubmed:abstractText | The relationship between the antibody responses to various influenza B type virus HA vaccines and protection against live B virus infection was investigated in Balb/c mice which had been inoculated intranasally with a combination of the HA vaccines and B subunit of cholera toxin (CTB) 4 weeks previously. The inoculation of HA vaccine, prepared from B/Ibaraki/2/85 (B/Ibaraki), B/Nagasaki/1/87 (B/Nagasaki) or B/Aichi/5/88 (B/Aichi) viruses, combined with CTB induced high levels of both nasal IgA and serum HI antibodies to any of B/Ibaraki, B/Nagasaki and B/Aichi viral antigens. Simultaneous inoculation of each CTB-combined HA vaccine provided complete protection against B/Ibaraki virus infection which is demonstrated by both rapid clearance of pulmonary virus and complete survival. On the other hand, the inoculation of HA vaccine prepared from B/Yamagata/16/88 (B/Yamagata) virus together with CTB induced only a low level of nasal IgA antibodies, cross-reactive to B/Ibaraki, B/Nagasaki and B/Aichi viral antigens and protected only partially against B/Ibaraki virus challenge. The involvement of the B type virus-specific immunity in this protection was suggested by the absence of protection against B/Ibaraki virus infection in mice previously inoculated with both A/PR/8/34 (H1N1) virus HA vaccine and CTB. These results suggest that antibodies to various influenza B viruses are cross-reactive to each B type virus antigens and that cross-protection against B virus infection could be conferred depending on the degree of B type virus cross-reactive immunity including secretory IgA antibodies. | lld:pubmed |
| pubmed-article:1965078 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1965078 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1965078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1965078 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1965078 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1965078 | pubmed:issn | 0264-410X | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:TamuraSS | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:KurataTT | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:UenoYY | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:HirabayashiYY | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:OyaAA | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:NagamineTT | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:KikutaKK | lld:pubmed |
| pubmed-article:1965078 | pubmed:author | pubmed-author:AizawaCC | lld:pubmed |
| pubmed-article:1965078 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1965078 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:1965078 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1965078 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1965078 | pubmed:pagination | 595-9 | lld:pubmed |
| pubmed-article:1965078 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:meshHeading | pubmed-meshheading:1965078-... | lld:pubmed |
| pubmed-article:1965078 | pubmed:year | 1990 | lld:pubmed |
| pubmed-article:1965078 | pubmed:articleTitle | Cross-protection against influenza B type virus infection by intranasal inoculation of the HA vaccines combined with cholera toxin B subunit. | lld:pubmed |
| pubmed-article:1965078 | pubmed:affiliation | Department of Pathology, National Institute of Health, Tokyo, Japan. | lld:pubmed |
| pubmed-article:1965078 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1965078 | lld:pubmed |
