| pubmed-article:19645482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C0014628 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C0425152 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1657294 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1961132 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C0935763 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1551022 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1961136 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C2348480 | lld:lifeskim |
| pubmed-article:19645482 | lifeskim:mentions | umls-concept:C1521840 | lld:lifeskim |
| pubmed-article:19645482 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:19645482 | pubmed:dateCreated | 2010-6-21 | lld:pubmed |
| pubmed-article:19645482 | pubmed:abstractText | 4-Substituted piperidine-derived trisubstituted ureas are reported as highly potent and selective inhibitors for sEH. The SAR outlines approaches to improve activity against sEH and reduce ion channel and CYP liability. With minimal off-target activity and a good PK profile, the benchmark 2d exhibited remarkable in vitro and ex vivo target engagement. The eutomer entA-2d also elicited vasodilation effect in rat mesenteric artery. | lld:pubmed |
| pubmed-article:19645482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19645482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19645482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19645482 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19645482 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ZhangXiaoping... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:KumarSanjeevS | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:RoySophieS | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ZhouGaochaoG | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:TataJames RJR | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:TongXinchunX | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:DingFa-XiangF... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:MitraKaushikK | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:TongVincentV | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ChenYuliY | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ShenHong CHC | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:CollettiSteve... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:Alonso-Galici... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:StevensonAndr... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ChenXiaoliX | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ZhangBeiB | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:DengQiaolinQ | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:BergerJoel... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:ChenHsuan-She... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:SoissonStephe... | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:PaiLee-YuhLY | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:XuSuoyuS | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:WangSiyiS | lld:pubmed |
| pubmed-article:19645482 | pubmed:author | pubmed-author:TsaiChristine... | lld:pubmed |
| pubmed-article:19645482 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19645482 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:19645482 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19645482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19645482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19645482 | pubmed:pagination | 5009-12 | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:meshHeading | pubmed-meshheading:19645482... | lld:pubmed |
| pubmed-article:19645482 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19645482 | pubmed:articleTitle | Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement. | lld:pubmed |
| pubmed-article:19645482 | pubmed:affiliation | Merck Research Laboratories, Merck & Co., Inc., Rahway, NJ 07065-0900, USA. hong_shen@merck.com | lld:pubmed |
| pubmed-article:19645482 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19645482 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19645482 | lld:chembl |
