| pubmed-article:19640482 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0033147 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0010097 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0162512 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0162783 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C1710236 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:19640482 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:19640482 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19640482 | pubmed:dateCreated | 2009-7-30 | lld:pubmed |
| pubmed-article:19640482 | pubmed:abstractText | Learning from experience requires knowing whether a past action resulted in a desired outcome. The prefrontal cortex and basal ganglia are thought to play key roles in such learning of arbitrary stimulus-response associations. Previous studies have found neural activity in these areas, similar to dopaminergic neurons' signals, that transiently reflect whether a response is correct or incorrect. However, it is unclear how this transient activity, which fades in under a second, influences actions that occur much later. Here, we report that single neurons in both areas show sustained, persistent outcome-related responses. Moreover, single behavioral outcomes influence future neural activity and behavior: behavioral responses are more often correct and single neurons more accurately discriminate between the possible responses when the previous response was correct. These long-lasting signals about trial outcome provide a way to link one action to the next and may allow reward signals to be combined over time to implement successful learning. | lld:pubmed |
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| pubmed-article:19640482 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19640482 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19640482 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19640482 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19640482 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19640482 | pubmed:issn | 1097-4199 | lld:pubmed |
| pubmed-article:19640482 | pubmed:author | pubmed-author:MillerEarl... | lld:pubmed |
| pubmed-article:19640482 | pubmed:author | pubmed-author:PasupathyAnit... | lld:pubmed |
| pubmed-article:19640482 | pubmed:author | pubmed-author:HistedMark... | lld:pubmed |
| pubmed-article:19640482 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19640482 | pubmed:day | 30 | lld:pubmed |
| pubmed-article:19640482 | pubmed:volume | 63 | lld:pubmed |
| pubmed-article:19640482 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19640482 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19640482 | pubmed:pagination | 244-53 | lld:pubmed |
| pubmed-article:19640482 | pubmed:dateRevised | 2010-12-17 | lld:pubmed |
