| pubmed-article:19635584 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C0023821 | lld:lifeskim |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C0677626 | lld:lifeskim |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C0085201 | lld:lifeskim |
| pubmed-article:19635584 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:19635584 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:19635584 | pubmed:dateCreated | 2009-11-3 | lld:pubmed |
| pubmed-article:19635584 | pubmed:abstractText | Whereas hepatocytes secrete the major human plasma high density lipoproteins (HDL)-protein, apo A-I, as lipid-free and lipidated species, the biogenic itineraries of apo A-II and apo E are unknown. Human plasma and HepG2 cell-derived apo A-II and apo E occur as monomers, homodimers and heterodimers. Dimerization of apo A-II, which is more lipophilic than apo A-I, is catalyzed by lipid surfaces. Thus, we hypothesized that lipidation of intracellular and secreted apo A-II exceeds that of apo A-I, and once lipidated, apo A-II dimerizes. Fractionation of HepG2 cell lysate and media by size exclusion chromatography showed that intracellular apo A-II and apo E are fully lipidated and occur on nascent HDL and VLDL respectively, while only 45% of intracellular apo A-I is lipidated. Secreted apo A-II and apo E occur on small HDL and on LDL and large HDL respectively. HDL particles containing both apo A-II and apo A-I form only after secretion from both HepG2 and Huh7 hepatoma cells. Apo A-II dimerizes intracellularly while intracellular apo E is monomeric but after secretion associates with HDL and subsequently dimerizes. Thus, HDL apolipoproteins A-I, A-II and E have distinct intracellular and post-secretory pathways of hepatic lipidation and dimerization in the process of HDL formation. These early forms of HDL are expected to follow different apolipoprotein-specific pathways through plasma remodeling and reverse cholesterol transport. | lld:pubmed |
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| pubmed-article:19635584 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19635584 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19635584 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19635584 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19635584 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19635584 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:19635584 | pubmed:issn | 0006-3002 | lld:pubmed |
| pubmed-article:19635584 | pubmed:author | pubmed-author:PownallHenry... | lld:pubmed |
| pubmed-article:19635584 | pubmed:author | pubmed-author:MasseyJohn... | lld:pubmed |
| pubmed-article:19635584 | pubmed:author | pubmed-author:GillardBaiba... | lld:pubmed |
| pubmed-article:19635584 | pubmed:author | pubmed-author:LinHu-Yu... | lld:pubmed |
| pubmed-article:19635584 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19635584 | pubmed:volume | 1791 | lld:pubmed |
| pubmed-article:19635584 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19635584 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19635584 | pubmed:pagination | 1125-32 | lld:pubmed |
| pubmed-article:19635584 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:19635584 | pubmed:meshHeading | pubmed-meshheading:19635584... | lld:pubmed |
| pubmed-article:19635584 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19635584 | pubmed:articleTitle | Apolipoproteins A-I, A-II and E are independently distributed among intracellular and newly secreted HDL of human hepatoma cells. | lld:pubmed |
| pubmed-article:19635584 | pubmed:affiliation | Section of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, One Baylor Plaza, MS-A601, Houston, TX 77030, USA. baibag@bcm.tmc.edu | lld:pubmed |
| pubmed-article:19635584 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19635584 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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