| pubmed-article:19627982 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19627982 | lifeskim:mentions | umls-concept:C0035552 | lld:lifeskim |
| pubmed-article:19627982 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:19627982 | lifeskim:mentions | umls-concept:C1708690 | lld:lifeskim |
| pubmed-article:19627982 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:19627982 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19627982 | pubmed:dateCreated | 2009-9-15 | lld:pubmed |
| pubmed-article:19627982 | pubmed:abstractText | The let-7 microRNA (miRNA) regulates developmental timing at the larval-to-adult transition in Caenorhabditis elegans. Dysregulation of let-7 results in irregular hypodermal and vulval development. Disrupted let-7 function is also a feature of human lung cancer. However, little is known about the mechanism and co-factors of let-7. Here we demonstrate that ribosomal protein RPS-14 is able to modulate let-7 function in C. elegans. The RPS-14 protein co-immunoprecipitated with the nematode Argonaute homolog, ALG-1. Reduction of rps-14 gene expression by RNAi suppressed the aberrant vulva and hypodermis development phenotypes of let-7(n2853) mutant animals and the mis-regulation of a reporter bearing the lin-41 3'UTR, a well established let-7 target. Our results indicate an interactive relationship between let-7 miRNA function and ribosomal protein RPS-14 in regulation of terminal differentiation that may help in understanding the mechanism of translational control by miRNAs. | lld:pubmed |
| pubmed-article:19627982 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19627982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19627982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19627982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19627982 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19627982 | pubmed:issn | 1095-564X | lld:pubmed |
| pubmed-article:19627982 | pubmed:author | pubmed-author:SlackFrank... | lld:pubmed |
| pubmed-article:19627982 | pubmed:author | pubmed-author:ChanShih-Peng... | lld:pubmed |
| pubmed-article:19627982 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19627982 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19627982 | pubmed:volume | 334 | lld:pubmed |
| pubmed-article:19627982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19627982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19627982 | pubmed:pagination | 152-60 | lld:pubmed |
| pubmed-article:19627982 | pubmed:dateRevised | 2010-12-17 | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:meshHeading | pubmed-meshheading:19627982... | lld:pubmed |
| pubmed-article:19627982 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19627982 | pubmed:articleTitle | Ribosomal protein RPS-14 modulates let-7 microRNA function in Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:19627982 | pubmed:affiliation | Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. | lld:pubmed |
| pubmed-article:19627982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19627982 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19627982 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:176006 | entrezgene:pubmed | pubmed-article:19627982 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19627982 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19627982 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19627982 | lld:pubmed |
