| pubmed-article:1962210 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1962210 | lifeskim:mentions | umls-concept:C0524637 | lld:lifeskim |
| pubmed-article:1962210 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:1962210 | lifeskim:mentions | umls-concept:C0028736 | lld:lifeskim |
| pubmed-article:1962210 | lifeskim:mentions | umls-concept:C1158517 | lld:lifeskim |
| pubmed-article:1962210 | pubmed:issue | 5037 | lld:pubmed |
| pubmed-article:1962210 | pubmed:dateCreated | 1992-1-9 | lld:pubmed |
| pubmed-article:1962210 | pubmed:abstractText | A polyamide nucleic acid (PNA) was designed by detaching the deoxyribose phosphate backbone of DNA in a computer model and replacing it with an achiral polyamide backbone. On the basis of this model, oligomers consisting of thymine-linked aminoethylglycyl units were prepared. These oligomers recognize their complementary target in double-stranded DNA by strand displacement. The displacement is made possible by the extraordinarily high stability of the PNA-DNA hybrids. The results show that the backbone of DNA can be replaced by a polyamide, with the resulting oligomer retaining base-specific hybridization. | lld:pubmed |
| pubmed-article:1962210 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1962210 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1962210 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1962210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1962210 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1962210 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1962210 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1962210 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:1962210 | pubmed:author | pubmed-author:NielsenP EPE | lld:pubmed |
| pubmed-article:1962210 | pubmed:author | pubmed-author:BuchardtOO | lld:pubmed |
| pubmed-article:1962210 | pubmed:author | pubmed-author:EgholmMM | lld:pubmed |
| pubmed-article:1962210 | pubmed:author | pubmed-author:BergR HRH | lld:pubmed |
| pubmed-article:1962210 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1962210 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:1962210 | pubmed:volume | 254 | lld:pubmed |
| pubmed-article:1962210 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1962210 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1962210 | pubmed:pagination | 1497-500 | lld:pubmed |
| pubmed-article:1962210 | pubmed:dateRevised | 2007-3-19 | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:meshHeading | pubmed-meshheading:1962210-... | lld:pubmed |
| pubmed-article:1962210 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1962210 | pubmed:articleTitle | Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. | lld:pubmed |
| pubmed-article:1962210 | pubmed:affiliation | Department of Biochemistry B, Panum Institute, Copenhagen, Denmark. | lld:pubmed |
| pubmed-article:1962210 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1962210 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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