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pubmed-article:19621428pubmed:abstractTextLittle is known on pathways involved in the pathogenesis of choroid plexus tumors (CPTs). The finding of overexpression of Wnt inhibitory factor-1 (Wif-1) prompted us to investigate the functional role of Wif-1 as well as nuclear accumulation of beta-catenin in CPT. In Z310 neoplastic choroid plexus epithelial cells, silencing of Wif1 expression increased proliferative activity not associated with increased canonical Wnt signaling. Nuclear beta-catenin accumulation was also lacking in a series of 16 CPT. In conclusion, our data show that Wif-1 inhibits proliferation of neoplastic choroid plexus epithelial cells, but argue against a role of canonical Wnt/wingless signaling in CPT.lld:pubmed
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pubmed-article:19621428pubmed:articleTitleRole of Wnt inhibitory factor-1 and Wnt/wingless signaling in choroid plexus tumors.lld:pubmed
pubmed-article:19621428pubmed:affiliationInstitute of Neuropathology, University Hospital Münster, Münster, Germany.lld:pubmed
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