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pubmed-article:19617322pubmed:abstractTextWhen a therapeutic drug is competitively displaced at the binding sites of serum proteins, the free fraction of the drug will be increased, with an increase in the manifestation of pharmacologic properties. In the case of molecular imaging probes, total clearance and tissue distribution are increased in such circumstances. The aim of this study was to observe the increase in cerebral accumulation of N-isopropyl-p-(123)I-iodoamphetamine ((123)I-IMP) using the protein-binding displacement method with amino acid infusion.lld:pubmed
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pubmed-article:19617322pubmed:articleTitleCompetitive displacement of serum protein binding of radiopharmaceuticals with amino acid infusion investigated with N-isopropyl-p-123I-iodoamphetamine.lld:pubmed
pubmed-article:19617322pubmed:affiliationRadiological Division, University of Miyazaki Hospital, University of Miyazaki, Miyazaki, Japan.lld:pubmed
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