| pubmed-article:19608871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C0684249 | lld:lifeskim |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C1515933 | lld:lifeskim |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C1335470 | lld:lifeskim |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:19608871 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:19608871 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19608871 | pubmed:dateCreated | 2009-7-27 | lld:pubmed |
| pubmed-article:19608871 | pubmed:abstractText | Matrilysin-1 (also called matrix metalloproteinase-7) is expressed in injured lung and in cancer but not in normal epithelia. Bronchiolization of the alveoli (BOA), a potential precursor of lung cancer, is a histologically distinct type of metaplasia that is composed of cells resembling airway epithelium in the alveolar compartment. We demonstrate that there is increased expression of matrilysin-1 in human lesions and BOA in the CC10-human achaete-scute homolog-1 transgenic mouse model. Forced expression of the matrilysin-1 gene in immortalized human normal airway epithelial BEAS-2B and HPLD1 cells, which do not normally express matrilysin-1, promoted cellular migration, suggesting a functional link for BOA formation via bronchiolar cell migration. In addition, matrilysin-1 stimulated proliferation and inhibited Fas-induced apoptosis, while a knockdown by RNA interference decreased cell growth, migration, and increased sensitivity to apoptosis. Western blotting demonstrated increased levels of phospho-p38 and phospho-Erk1/2 kinases after matrilysin-1 expression. Gene expression analysis uncovered several genes that were related to cell growth, migration/movement, and death, which could potentially facilitate bronchiolization. In vivo, the formation of BOA lesions was reduced when CC10-human achaete-scute homolog-1 mice were crossed with matrilysin-1 null mice and was correlated with reduced matrilysin-1 expression in BOA. We conclude that matrilysin-1 may play an important role in the bronchiolization of alveoli by promoting proliferation, migration, and attenuation of apoptosis involving multiple genes in the MAP kinase pathway. | lld:pubmed |
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| pubmed-article:19608871 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19608871 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19608871 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19608871 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19608871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19608871 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19608871 | pubmed:issn | 1525-2191 | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:BirrerMichael... | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:WangXiao-Yang... | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:LinnoilaR... | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:KimHeungnamH | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:DemelashAbeba... | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:OzbunLaurentL | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:Jensen-Taubma... | lld:pubmed |
| pubmed-article:19608871 | pubmed:author | pubmed-author:DakirEl... | lld:pubmed |
| pubmed-article:19608871 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19608871 | pubmed:volume | 175 | lld:pubmed |
| pubmed-article:19608871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19608871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19608871 | pubmed:pagination | 592-604 | lld:pubmed |
| pubmed-article:19608871 | pubmed:dateRevised | 2010-9-24 | lld:pubmed |
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| pubmed-article:19608871 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19608871 | pubmed:articleTitle | Matrilysin-1 mediates bronchiolization of alveoli, a potential premalignant change in lung cancer. | lld:pubmed |
| pubmed-article:19608871 | pubmed:affiliation | Experimental Pathology Section, Cell and Cancer Biology Branch, CCR, NCI, NIH, 37 Convent Drive; Room.1056B, Bethesda, Maryland 20892, USA. | lld:pubmed |
| pubmed-article:19608871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19608871 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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