| pubmed-article:19606833 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19606833 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19606833 | lifeskim:mentions | umls-concept:C0007603 | lld:lifeskim |
| pubmed-article:19606833 | lifeskim:mentions | umls-concept:C1450054 | lld:lifeskim |
| pubmed-article:19606833 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19606833 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:19606833 | pubmed:issue | 32 | lld:pubmed |
| pubmed-article:19606833 | pubmed:dateCreated | 2009-9-1 | lld:pubmed |
| pubmed-article:19606833 | pubmed:abstractText | It has long been recognized that cationic nanoparticles induce cell membrane permeability. Recently, it has been found that cationic nanoparticles induce the formation and/or growth of nanoscale holes in supported lipid bilayers. In this paper, we show that noncytotoxic concentrations of cationic nanoparticles induce 30-2000 pA currents in 293A (human embryonic kidney) and KB (human epidermoid carcinoma) cells, consistent with a nanoscale defect such as a single hole or group of holes in the cell membrane ranging from 1 to 350 nm(2) in total area. Other forms of nanoscale defects, including the nanoparticle porating agents adsorbing onto or intercalating into the lipid bilayer, are also consistent; although the size of the defect must increase to account for any reduction in ion conduction, as compared to a water channel. An individual defect forming event takes 1-100 ms, while membrane resealing may occur over tens of seconds. Patch-clamp data provide direct evidence for the formation of nanoscale defects in living cell membranes. The cationic polymer data are compared and contrasted with patch-clamp data obtained for an amphiphilic phenylene ethynylene antimicrobial oligomer (AMO-3), a small molecule that is proposed to make well-defined 3.4 nm holes in lipid bilayers. Here, we observe data that are consistent with AMO-3 making approximately 3 nm holes in living cell membranes. | lld:pubmed |
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| pubmed-article:19606833 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19606833 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19606833 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19606833 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19606833 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19606833 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19606833 | pubmed:issn | 1520-6106 | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:TewGregory... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:BakerJames... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:SomAbhigyanA | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:LopatinAnatol... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:OrrBradford... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:HollMark M... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:HongSeungpyoS | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:HesslerJessic... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:PutchakayalaK... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:PanamaBrian... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:MullenDouglas... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:DimaggioStass... | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:ChenJiumeiJ | lld:pubmed |
| pubmed-article:19606833 | pubmed:author | pubmed-author:KhanDamian... | lld:pubmed |
| pubmed-article:19606833 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19606833 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:19606833 | pubmed:volume | 113 | lld:pubmed |
| pubmed-article:19606833 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19606833 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19606833 | pubmed:pagination | 11179-85 | lld:pubmed |
| pubmed-article:19606833 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
| pubmed-article:19606833 | pubmed:meshHeading | pubmed-meshheading:19606833... | lld:pubmed |
| pubmed-article:19606833 | pubmed:meshHeading | pubmed-meshheading:19606833... | lld:pubmed |
| pubmed-article:19606833 | pubmed:meshHeading | pubmed-meshheading:19606833... | lld:pubmed |
| pubmed-article:19606833 | pubmed:meshHeading | pubmed-meshheading:19606833... | lld:pubmed |
| pubmed-article:19606833 | pubmed:meshHeading | pubmed-meshheading:19606833... | lld:pubmed |
| pubmed-article:19606833 | pubmed:meshHeading | pubmed-meshheading:19606833... | lld:pubmed |
| pubmed-article:19606833 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19606833 | pubmed:articleTitle | Cationic nanoparticles induce nanoscale disruption in living cell plasma membranes. | lld:pubmed |
| pubmed-article:19606833 | pubmed:affiliation | Chemistry Department, Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:19606833 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19606833 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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