| pubmed-article:19605474 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C0042774 | lld:lifeskim |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C0058980 | lld:lifeskim |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C1539341 | lld:lifeskim |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C1412215 | lld:lifeskim |
| pubmed-article:19605474 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:19605474 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:19605474 | pubmed:dateCreated | 2009-9-9 | lld:pubmed |
| pubmed-article:19605474 | pubmed:abstractText | The interferon-induced protein kinase RNA activated (PKR) is activated after virus infection. This activation is transient during the human immunodeficiency virus type 1 (HIV-1) infection of lymphocytes, and the protein is not activated at the peak of infection. We observed that interferon-induced adenosine deaminase acting on RNA 1-p150 (ADAR1-p150) and ADAR1-p110 expression increases while the virus replicates actively. Furthermore, both forms of ADAR1 show enhanced interactions with PKR at the peak of HIV infection, suggesting a role for this protein in the regulation of PKR activation. We observed that ADAR1-p150, as previously shown for the TAR RNA binding protein (TRBP), reverses the PKR inhibition of HIV expression and production in HEK 293T cells. This activity requires the Z-DNA binding motif and the three double-stranded RNA binding domains but not the catalytic domain. In astrocytic cells, ADAR1-p150 increased HIV expression and production to an extent similar to that of TRBP. Small interfering RNAs against ADAR1-p150 moderately decreased HIV production. These results indicate that two interferon-induced proteins, ADAR1 and PKR, have antagonistic functions on HIV production. They suggest that ADAR1 and TRBP belong to a multiprotein complex that inhibits PKR during the HIV infection of lymphocytes. | lld:pubmed |
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| pubmed-article:19605474 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19605474 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605474 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19605474 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19605474 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19605474 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19605474 | pubmed:issn | 1098-5514 | lld:pubmed |
| pubmed-article:19605474 | pubmed:author | pubmed-author:GatignolAnneA | lld:pubmed |
| pubmed-article:19605474 | pubmed:author | pubmed-author:MeursEliane... | lld:pubmed |
| pubmed-article:19605474 | pubmed:author | pubmed-author:BonnetMarionM | lld:pubmed |
| pubmed-article:19605474 | pubmed:author | pubmed-author:DaherAïchaA | lld:pubmed |
| pubmed-article:19605474 | pubmed:author | pubmed-author:ClerziusGuerl... | lld:pubmed |
| pubmed-article:19605474 | pubmed:author | pubmed-author:GélinasJean-F... | lld:pubmed |
| pubmed-article:19605474 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19605474 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:19605474 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19605474 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19605474 | pubmed:pagination | 10119-28 | lld:pubmed |
| pubmed-article:19605474 | pubmed:dateRevised | 2010-9-24 | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
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| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:meshHeading | pubmed-meshheading:19605474... | lld:pubmed |
| pubmed-article:19605474 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19605474 | pubmed:articleTitle | ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication. | lld:pubmed |
