| pubmed-article:19604696 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C0220908 | lld:lifeskim |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C1553497 | lld:lifeskim |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C1880355 | lld:lifeskim |
| pubmed-article:19604696 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:19604696 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:19604696 | pubmed:dateCreated | 2009-7-29 | lld:pubmed |
| pubmed-article:19604696 | pubmed:abstractText | Protein kinase B (PKB/AKT) is a promising and attractive therapeutic target in anticancer drug development. Herein, we report the findings of virtual screening for novel ATP-competitive inhibitors of AKT-2 using 2D- and 3D-similarity searching and sequential molecular docking with two crystal structures of AKT-2. Our multistep approach led to the identification of a low micromolar AKT-2 inhibitor (IC(50)=1.5 microM) with a novel scaffold. The experimentally validated inhibitor represents the starting point for an optimization program. | lld:pubmed |
| pubmed-article:19604696 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19604696 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19604696 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19604696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19604696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19604696 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19604696 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19604696 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19604696 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:19604696 | pubmed:author | pubmed-author:YuYongpingY | lld:pubmed |
| pubmed-article:19604696 | pubmed:author | pubmed-author:YaoLiboL | lld:pubmed |
| pubmed-article:19604696 | pubmed:author | pubmed-author:SinghNarender... | lld:pubmed |
| pubmed-article:19604696 | pubmed:author | pubmed-author:ShenLianglian... | lld:pubmed |
| pubmed-article:19604696 | pubmed:author | pubmed-author:GiulianottiMa... | lld:pubmed |
| pubmed-article:19604696 | pubmed:author | pubmed-author:Medina-Franco... | lld:pubmed |
| pubmed-article:19604696 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19604696 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19604696 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:19604696 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19604696 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19604696 | pubmed:pagination | 4634-8 | lld:pubmed |
| pubmed-article:19604696 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:meshHeading | pubmed-meshheading:19604696... | lld:pubmed |
| pubmed-article:19604696 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19604696 | pubmed:articleTitle | Discovery of a novel protein kinase B inhibitor by structure-based virtual screening. | lld:pubmed |
| pubmed-article:19604696 | pubmed:affiliation | Torrey Pines Institute for Molecular Studies, Port St Lucie, FL 34987, USA. jmedina@tpims.org | lld:pubmed |
| pubmed-article:19604696 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19604696 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:19604696 | lld:chembl |
