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pubmed-article:19596196pubmed:abstractTextTyrianthins A (1) and B (2), two new partially acylated glycolipid ester-type heterodimers were isolated from Ipomoea tyrianthina. Scammonic acid A was determined as the glycosidic acid in both monomeric units. Tyrianthin A (1) (IC(50) 0.24+/-0.09 microM and E(max) 81.80+/-0.98%), and tyrianthin B (2) (IC(50) 0.14+/-0.08 microM and E(max) 87.68+/-0.72%) showed significant in vitro relaxant effect on aortic rat rings, in endothelium- and concentration-dependent manners. Also, these compounds were able to increase the release of GABA and glutamic acid in brain cortex, and displayed weak antimycobacterial activity.lld:pubmed
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pubmed-article:19596196pubmed:articleTitleGlycolipid ester-type heterodimers from Ipomoea tyrianthina and their pharmacological activity.lld:pubmed
pubmed-article:19596196pubmed:affiliationCentro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, 62209 Cuernavaca, Morelos, Mexico.lld:pubmed
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