| pubmed-article:19592274 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C2350467 | lld:lifeskim |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C1413296 | lld:lifeskim |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C1865782 | lld:lifeskim |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C0332479 | lld:lifeskim |
| pubmed-article:19592274 | lifeskim:mentions | umls-concept:C0181687 | lld:lifeskim |
| pubmed-article:19592274 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19592274 | pubmed:dateCreated | 2009-7-16 | lld:pubmed |
| pubmed-article:19592274 | pubmed:abstractText | Mouse type I natural killer T cell receptors (iNKT TCRs) use a single V alpha 14-J alpha 18 sequence and V beta s that are almost always V beta 8.2, V beta 7, or V beta 2, although the basis of this differential usage is unclear. We showed that the V beta bias occurred as a consequence of the CDR2 beta loops determining the affinity of the iNKT TCR for CD1d-glycolipids, thus controlling positive selection. Within a conserved iNKT-TCR-CD1d docking framework, these inherent V beta-CD1d affinities are further modulated by the hypervariable CDR3 beta loop, thereby defining a functional interplay between the two iNKT TCR CDR beta loops. These V beta biases revealed a broadly hierarchical response in which V beta 8.2 > V beta 7 > V beta 2 in the recognition of diverse CD1d ligands. This restriction of the iNKT TCR repertoire during thymic selection paradoxically ensures that each peripheral iNKT cell recognizes a similar spectrum of antigens. | lld:pubmed |
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| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19592274 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19592274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19592274 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19592274 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19592274 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:MarrackPhilip... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:GodfreyDale... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:PellicciDanie... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:McCluskeyJame... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:GapinLaurentL | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:CerundoloVinc... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:HowellAmy RAR | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:Kjer-NielsenL... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:RossjohnJamie... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:MatsudaJennif... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:MallevaeyThie... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:PatelOnishaO | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:RichardsonSte... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:Scott-BrowneJ... | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:ThakurMeenaM | lld:pubmed |
| pubmed-article:19592274 | pubmed:author | pubmed-author:YoungMary HMH | lld:pubmed |
| pubmed-article:19592274 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19592274 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:19592274 | pubmed:volume | 31 | lld:pubmed |
| pubmed-article:19592274 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19592274 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19592274 | pubmed:pagination | 60-71 | lld:pubmed |
| pubmed-article:19592274 | pubmed:dateRevised | 2011-1-26 | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:meshHeading | pubmed-meshheading:19592274... | lld:pubmed |
| pubmed-article:19592274 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19592274 | pubmed:articleTitle | T cell receptor CDR2 beta and CDR3 beta loops collaborate functionally to shape the iNKT cell repertoire. | lld:pubmed |
| pubmed-article:19592274 | pubmed:affiliation | Department of Immunology, University of Colorado Denver and National Jewish Health, Denver, CO 80206, USA. | lld:pubmed |
| pubmed-article:19592274 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19592274 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19592274 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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