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pubmed-article:19590405pubmed:abstractTextA family of histone deacetylases (HDACs) mediates chromatin remodeling, and repression of gene expression. Deacetylation of histones within the HIV-1 long terminal repeat (LTR) by HDACs plays a key role in the maintenance of latency, whereas acetylation of histones about the LTR is linked to proviral expression and escape of HIV from latency. Global HDAC inhibition may adversely affect host gene expression, leading to cellular toxicities. Potent inhibitors selective for HDACs that maintain LTR repression could be ideal antilatency therapeutics.lld:pubmed
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pubmed-article:19590405pubmed:articleTitleExpression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors.lld:pubmed
pubmed-article:19590405pubmed:affiliationDepartment of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 7599-7435, USA.lld:pubmed
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