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pubmed-article:19590239pubmed:abstractTextPodocytes play a critical role in the pathogenesis of glomerulosclerosis. Increasing evidence suggests that aldosterone (ALD) is involved in the initiation and progression of glomerular damage. It is, however, unknown whether there is a direct injurious effect of ALD on podocytes. Therefore, in the present study, we evaluated the effect of ALD on podocyte apoptosis and studied the role of phosphatidylinositol 3-kinase/Akt (PI3-K/Akt) and p38 mitogen-activated protein kinase (p38MAPK) signaling pathways in this process.lld:pubmed
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pubmed-article:19590239pubmed:authorpubmed-author:JiaJunyaJlld:pubmed
pubmed-article:19590239pubmed:copyrightInfoCopyright 2009 S. Karger AG, Basel.lld:pubmed
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pubmed-article:19590239pubmed:articleTitleAldosterone induces apoptosis in rat podocytes: role of PI3-K/Akt and p38MAPK signaling pathways.lld:pubmed
pubmed-article:19590239pubmed:affiliationDivision of Nephrology, Renmin Hospital of Wuhan University, Wuhan 430060, China.lld:pubmed
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