| pubmed-article:19589379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0007586 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0068563 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0392744 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19589379 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19589379 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19589379 | pubmed:dateCreated | 2009-8-18 | lld:pubmed |
| pubmed-article:19589379 | pubmed:abstractText | It has been demonstrated that during neurogenesis in the mammalian brain, cell-cycle lengthening in neuronal progenitors may cause them to switch from proliferation to neuron-generating division. However, little is known about the cellular mechanisms involved in lengthening of the cell cycle. Growth-associated protein-43 (GAP-43) is a nervous system-specific protein whose expression in proliferating neuroblasts is related to neurogenesis. In this study, we investigated the effect of GAP-43 on cell-cycle progression in transgenic fibroblast cells. Using cumulative bromodeoxyuridine labeling, cell-cycle kinetics in GAP-43-transgenic and control NIH 3T3 cells were analyzed. Our data demonstrate that expression of GAP-43 in fibroblasts results in lengthening of the cell cycle compared to control fibroblasts. The mechanism by which GAP-43 mediated this effect appeared to involve increasing the time spent by the cells in the G(1) phase of the cell cycle. | lld:pubmed |
| pubmed-article:19589379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19589379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19589379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19589379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19589379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19589379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19589379 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:19589379 | pubmed:issn | 1873-474X | lld:pubmed |
| pubmed-article:19589379 | pubmed:author | pubmed-author:XuQunyuanQ | lld:pubmed |
| pubmed-article:19589379 | pubmed:author | pubmed-author:JiangXiaohuaX | lld:pubmed |
| pubmed-article:19589379 | pubmed:author | pubmed-author:ZhaoJunpengJ | lld:pubmed |
| pubmed-article:19589379 | pubmed:author | pubmed-author:XuChangleiC | lld:pubmed |
| pubmed-article:19589379 | pubmed:author | pubmed-author:YaoYajuanY | lld:pubmed |
| pubmed-article:19589379 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19589379 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:19589379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19589379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19589379 | pubmed:pagination | 531-7 | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:meshHeading | pubmed-meshheading:19589379... | lld:pubmed |
| pubmed-article:19589379 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19589379 | pubmed:articleTitle | Expression of the neural specific protein, GAP-43, dramatically lengthens the cell cycle in fibroblasts. | lld:pubmed |
| pubmed-article:19589379 | pubmed:affiliation | Beijing Institute for Neuroscience, Beijing Center for Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing 100069, PR China. | lld:pubmed |
| pubmed-article:19589379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19589379 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14432 | entrezgene:pubmed | pubmed-article:19589379 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19589379 | lld:entrezgene |
