| pubmed-article:19587379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C1282910 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0034790 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0024518 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0679058 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C1510996 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C1947910 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C1547699 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:19587379 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:19587379 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:19587379 | pubmed:dateCreated | 2009-9-4 | lld:pubmed |
| pubmed-article:19587379 | pubmed:abstractText | Adoptive transfer of T cells expressing transgenic T-cell receptors (TCRs) with antitumor function is a hopeful new therapy for patients with advanced tumors; however, there is a critical bottleneck in identifying high-affinity TCR specificities needed to treat different malignancies. We have developed a strategy using autologous dendritic cells cotransfected with RNA encoding an allogeneic major histocompatibility complex molecule and a tumor-associated antigen to obtain allo-restricted peptide-specific T cells having superior capacity to recognize tumor cells and higher functional avidity. This approach provides maximum flexibility because any major histocompatibility complex molecule and any tumor-associated antigen can be combined in the dendritic cells used for priming of autologous T cells. TCRs of allo-restricted T cells, when expressed as transgenes in activated peripheral blood lymphocytes, transferred superior function compared with self-restricted TCR. This approach allows high-avidity T cells and TCR specific for tumor-associated self-peptides to be easily obtained for direct adoptive T-cell therapy or for isolation of therapeutic transgenic TCR sequences. | lld:pubmed |
| pubmed-article:19587379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19587379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:19587379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19587379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19587379 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19587379 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:BuschDirk HDH | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:SchendelDolor... | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:Frankenberger... | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:SchiemannMatt... | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:PohlaHeikeH | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:UckertWolfgan... | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:MilosevicSlav... | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:WildeSusanneS | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:SommermeyerDa... | lld:pubmed |
| pubmed-article:19587379 | pubmed:author | pubmed-author:SprangerStefa... | lld:pubmed |
| pubmed-article:19587379 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19587379 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:19587379 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:19587379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19587379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19587379 | pubmed:pagination | 2131-9 | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:meshHeading | pubmed-meshheading:19587379... | lld:pubmed |
| pubmed-article:19587379 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19587379 | pubmed:articleTitle | Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity. | lld:pubmed |
| pubmed-article:19587379 | pubmed:affiliation | Institute of Molecular Immunology, Helmholtz Zentrum München, German Research Center for Environmental Health, Marchioninistrasse 25, Munich, Germany. | lld:pubmed |
| pubmed-article:19587379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19587379 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
