Evaluation of early osteochondral defect repair in a rabbit model utilizing fourier transform-infrared imaging spectroscopy, magnetic resonance imaging, and quantitative T2 mapping.

Source:http://linkedlifedata.com/resource/pubmed/id/19586313

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Authors

Moynihan DP, Potter HG, Ryaby JT, Kim M, Foo LF, Uggen C, Pleshko N, Lyman S, Grande DA

Affiliation

Hospital for Special Surgery, New York, NY, USA.

Abstract

Evaluation of the morphology and matrix composition of repair cartilage is a critical step toward understanding the natural history of cartilage repair and efficacy of potential therapeutics. In the current study, short-term articular cartilage repair (3 and 6 weeks) was evaluated in a rabbit osteochondral defect model treated with thrombin peptide (TP-508) using magnetic resonance imaging (MRI), quantitative T2 mapping, and Fourier transform-infrared imaging spectroscopy (FT-IRIS).

PMID
19586313

Publication types

Evaluation Studies; Research Support, N.I.H., Extramural