| pubmed-article:19580783 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19580783 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:19580783 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:19580783 | lifeskim:mentions | umls-concept:C0085224 | lld:lifeskim |
| pubmed-article:19580783 | lifeskim:mentions | umls-concept:C1425071 | lld:lifeskim |
| pubmed-article:19580783 | lifeskim:mentions | umls-concept:C0917728 | lld:lifeskim |
| pubmed-article:19580783 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19580783 | pubmed:dateCreated | 2009-8-11 | lld:pubmed |
| pubmed-article:19580783 | pubmed:abstractText | TTRAP is a PML-NB protein that is involved in the NF-kappaB signaling pathway. TTRAP was recently identified by yeast two-hybrid analysis as a HIV-1 integrase (HIV-1 IN) interacting protein. This interaction was verified by co-immunoprecipitation, GST pull-down, and intracellular imaging, and deletion assays suggested that the N-terminal 180 residues of TTRAP are responsible for the interaction. In stable TTRAP knock-down cell lines, the integration of viral vectors decreased significantly compared with non-silenced cell lines. Conversely, overexpression of TTRAP by transient transfection increased the percentage of integration events. This is the first time that TTRAP has been shown to interact with HIV-1 IN and facilitate lentiviral vector integration. These findings reveal a new function of TTRAP and expand our understanding of the cellular response to HIV infection. The interaction between TTRAP and HIV-1 IN may be useful in designing new anti-viral strategies as well as for improving the efficiency of lentiviral-vector-mediated gene delivery. | lld:pubmed |
| pubmed-article:19580783 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19580783 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580783 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19580783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19580783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19580783 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19580783 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:ChenJin-zhong... | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:TianLingL | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:JiaWilliamW | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:HuangLuL | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:XueJing-lunJL | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:ZhangJian-qiJ... | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:LiWen-juanWJ | lld:pubmed |
| pubmed-article:19580783 | pubmed:author | pubmed-author:WangJing-jing... | lld:pubmed |
| pubmed-article:19580783 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19580783 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:19580783 | pubmed:volume | 387 | lld:pubmed |
| pubmed-article:19580783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19580783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19580783 | pubmed:pagination | 256-60 | lld:pubmed |
| pubmed-article:19580783 | pubmed:dateRevised | 2011-10-13 | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:meshHeading | pubmed-meshheading:19580783... | lld:pubmed |
| pubmed-article:19580783 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19580783 | pubmed:articleTitle | Cellular protein TTRAP interacts with HIV-1 integrase to facilitate viral integration. | lld:pubmed |
| pubmed-article:19580783 | pubmed:affiliation | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, China. | lld:pubmed |
| pubmed-article:19580783 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19580783 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19580783 | lld:entrezgene |
