| pubmed-article:19578365 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C2350277 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C0027962 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C0027960 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C0221912 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C1515498 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C1521113 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19578365 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:19578365 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19578365 | pubmed:dateCreated | 2009-7-29 | lld:pubmed |
| pubmed-article:19578365 | pubmed:abstractText | A high melanocytic nevi count is the strongest known risk factor for cutaneous melanoma. We conducted a genome-wide association study for nevus count using 297,108 SNPs in 1,524 twins, with validation in an independent cohort of 4,107 individuals. We identified strongly associated variants in MTAP, a gene adjacent to the familial melanoma susceptibility locus CDKN2A on 9p21 (rs4636294, combined P = 3.4 x 10(-15)), as well as in PLA2G6 on 22q13.1 (rs2284063, combined P = 3.4 x 10(-8)). In addition, variants in these two loci showed association with melanoma risk in 3,131 melanoma cases from two independent studies, including rs10757257 at 9p21, combined P = 3.4 x 10(-8), OR = 1.23 (95% CI = 1.15-1.30) and rs132985 at 22q13.1, combined P = 2.6 x 10(-7), OR = 1.23 (95% CI = 1.15-1.30). This provides the first report of common variants associated to nevus number and demonstrates association of these variants with melanoma susceptibility. | lld:pubmed |
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| pubmed-article:19578365 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:19578365 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19578365 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19578365 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19578365 | pubmed:issn | 1546-1718 | lld:pubmed |
| pubmed-article:19578365 | pubmed:author | pubmed-author:DuffyDavid... | lld:pubmed |
| pubmed-article:19578365 | pubmed:author | pubmed-author:ElderDavid... | lld:pubmed |
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| pubmed-article:19578365 | pubmed:author | pubmed-author:MartinNichola... | lld:pubmed |
| pubmed-article:19578365 | pubmed:author | pubmed-author:MontgomeryGra... | lld:pubmed |
| pubmed-article:19578365 | pubmed:author | pubmed-author:FalchiMarioM | lld:pubmed |
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| pubmed-article:19578365 | pubmed:author | pubmed-author:ZhaoZhen ZZZ | lld:pubmed |
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| pubmed-article:19578365 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19578365 | pubmed:volume | 41 | lld:pubmed |
| pubmed-article:19578365 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19578365 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19578365 | pubmed:pagination | 915-9 | lld:pubmed |
| pubmed-article:19578365 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:19578365 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19578365 | pubmed:articleTitle | Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi. | lld:pubmed |
| pubmed-article:19578365 | pubmed:affiliation | Department of Twin Research & Genetic Epidemiology, Kings College London, St. Thomas' Hospital Campus, London, UK. m.falchi@imperial.ac.uk | lld:pubmed |
| pubmed-article:19578365 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19578365 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19578365 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:19578365 | pubmed:publicationType | Twin Study | lld:pubmed |
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