Linked Life Data

19578281

Source:http://linkedlifedata.com/resource/pubmed/id/19578281

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19578281rdf:typepubmed:Citationlld:pubmed
pubmed-article:19578281lifeskim:mentionsumls-concept:C0034693lld:lifeskim
pubmed-article:19578281lifeskim:mentionsumls-concept:C0034392lld:lifeskim
pubmed-article:19578281lifeskim:mentionsumls-concept:C0033095lld:lifeskim
pubmed-article:19578281lifeskim:mentionsumls-concept:C1383860lld:lifeskim
pubmed-article:19578281lifeskim:mentionsumls-concept:C0205263lld:lifeskim
pubmed-article:19578281lifeskim:mentionsumls-concept:C1292733lld:lifeskim
pubmed-article:19578281pubmed:issue6lld:pubmed
pubmed-article:19578281pubmed:dateCreated2009-7-6lld:pubmed
pubmed-article:19578281pubmed:abstractTextInhibition of cardiac hypertrophy leads to a significant reduction in cardiovascular mortality and morbidity. Quercetin is by far the most abundant flavonoid and believed to ameliorate cardiovascular disease. Therefore, we investigated whether quercetin supplementation could attenuate the development of cardiac hypertrophy induced by pressure overload. Three weeks after suprarenal transverse abdominal aortic constriction, heart to body weight (HW/BW) ratio increased compared to the sham group (3.40 +/- 0.06 mg/g versus 2.83 +/- 0.02 mg/g, P<0.001). The quercetin administered group showed complete inhibition of cardiac hypertrophy (2.85 +/- 0.01 mg/g, P<0.001). Malonyldialdehyde production induced by pressure overload was suppressed by quercetin. The activities of extracellular signal-regulated kinase (ERK1/2), p38 MAP kinase, Akt and GSK-3beta were significantly increased with pressure overload and attenuated by quercetin treatment. We conclude that quercetin appears to block the development of cardiac hypertrophy induced by pressure overload in rats and that these effects may be mediated through reduced oxidant status and inhibition of ERK1/2, p38 MAP kinase, Akt and GSK-3beta activities.lld:pubmed
pubmed-article:19578281pubmed:languageenglld:pubmed
pubmed-article:19578281pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:citationSubsetIMlld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19578281pubmed:statusMEDLINElld:pubmed
pubmed-article:19578281pubmed:monthJunlld:pubmed
pubmed-article:19578281pubmed:issn0916-7250lld:pubmed
pubmed-article:19578281pubmed:authorpubmed-author:KimChan-Hyung...lld:pubmed
pubmed-article:19578281pubmed:authorpubmed-author:LeeYong-SoonY...lld:pubmed
pubmed-article:19578281pubmed:authorpubmed-author:AhnHee-YulHYlld:pubmed
pubmed-article:19578281pubmed:authorpubmed-author:HongJang-SooJ...lld:pubmed
pubmed-article:19578281pubmed:authorpubmed-author:HaoJiaJlld:pubmed
pubmed-article:19578281pubmed:authorpubmed-author:HanJing-JunJJlld:pubmed
pubmed-article:19578281pubmed:issnTypePrintlld:pubmed
pubmed-article:19578281pubmed:volume71lld:pubmed
pubmed-article:19578281pubmed:ownerNLMlld:pubmed
pubmed-article:19578281pubmed:authorsCompleteYlld:pubmed
pubmed-article:19578281pubmed:pagination737-43lld:pubmed
pubmed-article:19578281pubmed:dateRevised2011-11-2lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:meshHeadingpubmed-meshheading:19578281...lld:pubmed
pubmed-article:19578281pubmed:year2009lld:pubmed
pubmed-article:19578281pubmed:articleTitleQuercetin prevents cardiac hypertrophy induced by pressure overload in rats.lld:pubmed
pubmed-article:19578281pubmed:affiliationDepartment of Thoracic and Cardio vascular Surgery, Guang Dong Medical College FuTian Hospital, China.lld:pubmed
pubmed-article:19578281pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19578281pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed