Linked Life Data

19574726

Source:http://linkedlifedata.com/resource/pubmed/id/19574726

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:19574726rdf:typepubmed:Citationlld:pubmed
pubmed-article:19574726lifeskim:mentionsumls-concept:C0031809lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C1280551lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0018792lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0031327lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0004245lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0991556lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0164155lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0205191lld:lifeskim
pubmed-article:19574726lifeskim:mentionsumls-concept:C0521115lld:lifeskim
pubmed-article:19574726pubmed:issue3lld:pubmed
pubmed-article:19574726pubmed:dateCreated2009-7-17lld:pubmed
pubmed-article:19574726pubmed:abstractTextPharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects were simultaneously assessed using chronic atrioventricular block dogs. After application of the patch (9.8 mg/kg), pilsicainide was continuously absorbed through the skin with a C(max) of 0.49 +/- 0.13 microg/ml, while its plasma concentration was kept above the clinically reported minimum effective plasma concentration for 2 - 8 h. Inter-atrial conduction time was significantly prolonged, whereas statistically significant prolongation was not detected in the atrial effective refractory period. Prolongation of the cycle length of atrial fibrillation and anti-fibrillatory action were confirmed. Thus, pilsicainide can be absorbed transdermally to exert long-lasting electropharmacological effects leading to anti-atrial fibrillatory action.lld:pubmed
pubmed-article:19574726pubmed:languageenglld:pubmed
pubmed-article:19574726pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19574726pubmed:citationSubsetIMlld:pubmed
pubmed-article:19574726pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19574726pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19574726pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:19574726pubmed:statusMEDLINElld:pubmed
pubmed-article:19574726pubmed:monthJullld:pubmed
pubmed-article:19574726pubmed:issn1347-8613lld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:TakaharaAkira...lld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:IwasakiHirosh...lld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:NakamuraYujiYlld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:NagaiTakeshiTlld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:SugiyamaAtsus...lld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:SatohYoshioki...lld:pubmed
pubmed-article:19574726pubmed:authorpubmed-author:ShinkaiNorihi...lld:pubmed
pubmed-article:19574726pubmed:issnTypePrintlld:pubmed
pubmed-article:19574726pubmed:volume110lld:pubmed
pubmed-article:19574726pubmed:ownerNLMlld:pubmed
pubmed-article:19574726pubmed:authorsCompleteYlld:pubmed
pubmed-article:19574726pubmed:pagination410-4lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:meshHeadingpubmed-meshheading:19574726...lld:pubmed
pubmed-article:19574726pubmed:year2009lld:pubmed
pubmed-article:19574726pubmed:articleTitleSimultaneous assessment of pharmacokinetics of pilsicainide transdermal patch and its electropharmacological effects on atria of chronic atrioventricular block dogs.lld:pubmed
pubmed-article:19574726pubmed:affiliationDepartment of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan.lld:pubmed
pubmed-article:19574726pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19574726pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed