| pubmed-article:19571328 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C0025663 | lld:lifeskim |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C0242485 | lld:lifeskim |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C1426592 | lld:lifeskim |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C0439810 | lld:lifeskim |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:19571328 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:19571328 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19571328 | pubmed:dateCreated | 2009-12-16 | lld:pubmed |
| pubmed-article:19571328 | pubmed:abstractText | The proprotein convertase subtilisin kexin-9 (PCSK9) circulates in plasma as mature and furin-cleaved forms. A polyclonal antibody against human PCSK9 was used to develop an ELISA that measures total plasma PCSK9 rather than only the mature form. A cross-sectional study evaluated plasma levels in normal (n = 254) and hypercholesterolemic (n = 200) subjects treated or untreated with statins or statin plus ezetimibe. In controls, mean plasma PCSK9 (89.5 +/- 31.9 ng/ml) correlated positively with age, total cholesterol, LDL-cholesterol (LDL-C), triglycerides, and fasting glucose. Sequencing PCSK9 from individuals at the extremes of the normal PCSK9 distribution identified a new loss-of-function R434W variant associated with lower levels of circulating PCSK9 and LDL-C. In hypercholesterolemic subjects, PCSK9 levels were higher than in controls (99.3 +/- 31.7 ng/ml, P < 0.04) and increased in proportion to the statin dose, combined or not with ezetimibe. In treated patients (n = 139), those with familial hypercholesterolemia (FH; due to LDL receptor gene mutations) had higher PCSK9 values than non-FH (147.01 +/- 42.5 vs. 127.2 +/- 40.8 ng/ml, P < 0.005), but LDL-C reduction correlated positively with achieved plasma PCSK9 levels to a similar extent in both subsets (r = 0.316, P < 0.02 in FH and r = 0.275, P < 0.009 in non-FH). The detection of circulating PCSK9 in both FH and non-FH subjects means that this assay could be used to monitor response to therapy in a wide range of patients. | lld:pubmed |
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| pubmed-article:19571328 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19571328 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19571328 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19571328 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19571328 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:19571328 | pubmed:issn | 0022-2275 | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:GenestJacques... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:SeidahNabil... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:BenjannetSuza... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:ParéGuillaume... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:TremblayMiche... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:JacquesHélène... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:BernierLiseL | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:DavignonJeanJ | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:BouletLucieL | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:DubucGenevièv... | lld:pubmed |
| pubmed-article:19571328 | pubmed:author | pubmed-author:HamelinJoséeJ | lld:pubmed |
| pubmed-article:19571328 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19571328 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:19571328 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19571328 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19571328 | pubmed:pagination | 140-9 | lld:pubmed |
| pubmed-article:19571328 | pubmed:dateRevised | 2011-7-19 | lld:pubmed |
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