| pubmed-article:19570783 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19570783 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19570783 | lifeskim:mentions | umls-concept:C0334108 | lld:lifeskim |
| pubmed-article:19570783 | lifeskim:mentions | umls-concept:C0003209 | lld:lifeskim |
| pubmed-article:19570783 | lifeskim:mentions | umls-concept:C0031437 | lld:lifeskim |
| pubmed-article:19570783 | lifeskim:mentions | umls-concept:C0333051 | lld:lifeskim |
| pubmed-article:19570783 | lifeskim:mentions | umls-concept:C1515999 | lld:lifeskim |
| pubmed-article:19570783 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:19570783 | pubmed:dateCreated | 2009-7-2 | lld:pubmed |
| pubmed-article:19570783 | pubmed:abstractText | T-regulatory (Treg) cells play a major role in cancer by suppressing protective antitumor immune responses. A series of observations (from a single laboratory) suggest that Treg cells are protective in cancer by virtue of their ability to control cancer-associated inflammation in an interleukin (IL)-10-dependent manner. Here, we report that the ability of Treg cells to produce IL-10 and control inflammation is lost in the course of progressive disease in a mouse model of hereditary colon cancer. Treg cells that expand in adenomatous polyps no longer produce IL-10 and instead switch to production of IL-17. Aberrant Treg cells from polyp-ridden mice promote rather than suppress focal mastocytosis, a critical tumor-promoting inflammatory response. The cells, however, maintain other Treg characteristics, including their inability to produce IL-2 and ability to suppress proliferation of stimulated CD4 T cells. By promoting inflammation and suppressing T-helper functions, these cells act as a double-edged knife propagating tumor growth. | lld:pubmed |
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| pubmed-article:19570783 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19570783 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19570783 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19570783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19570783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19570783 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19570783 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:GounariFotini... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:KhazaieKhasha... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:StromTerry... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:GurishMichael... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:BeckhovePhili... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:BlatnerNichol... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:GounarisElias... | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:MagnussonFayF | lld:pubmed |
| pubmed-article:19570783 | pubmed:author | pubmed-author:DennisKristen... | lld:pubmed |
| pubmed-article:19570783 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19570783 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:19570783 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:19570783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19570783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19570783 | pubmed:pagination | 5490-7 | lld:pubmed |
| pubmed-article:19570783 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
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