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pubmed-article:19558692pubmed:abstractTextMetabolic perturbations arising from malignant transformation have not been systematically characterized in human lung cancers in situ. Stable isotope resolved metabolomic analysis (SIRM) enables functional analysis of gene dysregulations in lung cancer. To this purpose, metabolic changes were investigated by infusing uniformly labeled 13C-glucose into human lung cancer patients, followed by resection and processing of paired non-cancerous lung and non small cell carcinoma tissues. NMR and GC-MS were used for 13C-isotopomer-based metabolomic analysis of the extracts of tissues and blood plasma.lld:pubmed
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pubmed-article:19558692pubmed:articleTitleAltered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM).lld:pubmed
pubmed-article:19558692pubmed:affiliationDepartment of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA. twmfan@gmail.comlld:pubmed
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