| pubmed-article:19558602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C0017638 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C0010656 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C1415288 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C1704970 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:19558602 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:19558602 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19558602 | pubmed:dateCreated | 2009-7-7 | lld:pubmed |
| pubmed-article:19558602 | pubmed:abstractText | Glioblastoma multiforme (GBM) is the most invasive and undifferentiated type of brain tumour, and so surgical interventions are ineffective. We found that GluR2 is absent in fast-growing GBM-derived tumour stem cells and high-grade glioma specimens, but is expressed in slow-growing stem cells and low-grade glioma specimens. More remarkably, GluR2 overexpression in U-87MG cells inhibits proliferation by inactivating extracellular signal-regulated kinase (ERK)1/2-Src phosphorylation and induces apoptosis. Mechanistically, we observed that the scaffold protein GRIP is essential for the effect of GluR2 on ERK-Src inactivation. These findings indicate that the absence of the GluR2 subunit favours malignancy. | lld:pubmed |
| pubmed-article:19558602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19558602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19558602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19558602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19558602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19558602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19558602 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19558602 | pubmed:issn | 1460-9568 | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:GalliRossella... | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:PassafaroMari... | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:BindaElenaE | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:BelloLorenzoL | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:BerettaFrance... | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:VerpelliChiar... | lld:pubmed |
| pubmed-article:19558602 | pubmed:author | pubmed-author:BassaniSilvia... | lld:pubmed |
| pubmed-article:19558602 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19558602 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:19558602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19558602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19558602 | pubmed:pagination | 25-34 | lld:pubmed |
| pubmed-article:19558602 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:19558602 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19558602 | pubmed:articleTitle | The GluR2 subunit inhibits proliferation by inactivating Src-MAPK signalling and induces apoptosis by means of caspase 3/6-dependent activation in glioma cells. | lld:pubmed |
| pubmed-article:19558602 | pubmed:affiliation | DTI Dulbecco Telethon Institute, Via Vanvitelli 32, Milan 20129, Italy. | lld:pubmed |
| pubmed-article:19558602 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19558602 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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