| pubmed-article:1955574 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C2926606 | lld:lifeskim |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C0007682 | lld:lifeskim |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C0205462 | lld:lifeskim |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C2607943 | lld:lifeskim |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C0333348 | lld:lifeskim |
| pubmed-article:1955574 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:1955574 | pubmed:issue | 1-3 | lld:pubmed |
| pubmed-article:1955574 | pubmed:dateCreated | 1992-1-2 | lld:pubmed |
| pubmed-article:1955574 | pubmed:abstractText | The brains of pathogen-free autoimmune MRL/lpr, NZBWF1 and NZB mice were examined for central nervous system (CNS) inflammation in premoribund 8-week-old animals and at ages when active systemic lupus erythematosus (SLE) was present. CNS inflammation was observed only in MRL/lpr mice. Immunohistochemical studies of brains from young MRL/lpr mice found that infiltrates were composed primarily of CD4+ cells. Older MRL/lpr mice (22 and 26 weeks of age) had CD4+ cells predominantly, but CD8+ and B220+ cells were also present. Perivascular leakage of IgG was a prominent and unexpected finding in the MRL/lpr model. Congenic MRL/+ mice with late-onset autoimmunity had no inflammatory cells in brain tissue, and there was no perivascular staining with IgG or albumin. Our findings suggest that MRL/lpr mice are a useful model for studies of lupus-associated CNS inflammatory disease, and perivascular leakage may be a primary mechanism for entry of IgG into the brain. | lld:pubmed |
| pubmed-article:1955574 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1955574 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1955574 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1955574 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1955574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1955574 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1955574 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1955574 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:1955574 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:1955574 | pubmed:author | pubmed-author:WalkerS ESE | lld:pubmed |
| pubmed-article:1955574 | pubmed:author | pubmed-author:BaslerJJ | lld:pubmed |
| pubmed-article:1955574 | pubmed:author | pubmed-author:JohnsonG CGC | lld:pubmed |
| pubmed-article:1955574 | pubmed:author | pubmed-author:Besch-Willifo... | lld:pubmed |
| pubmed-article:1955574 | pubmed:author | pubmed-author:VogelweidC... | lld:pubmed |
| pubmed-article:1955574 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1955574 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:1955574 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1955574 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1955574 | pubmed:pagination | 89-99 | lld:pubmed |
| pubmed-article:1955574 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:meshHeading | pubmed-meshheading:1955574-... | lld:pubmed |
| pubmed-article:1955574 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1955574 | pubmed:articleTitle | Inflammatory central nervous system disease in lupus-prone MRL/lpr mice: comparative histologic and immunohistochemical findings. | lld:pubmed |
| pubmed-article:1955574 | pubmed:affiliation | Department of Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65212. | lld:pubmed |
| pubmed-article:1955574 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1955574 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:1955574 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1955574 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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