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pubmed-article:19555158pubmed:dateCreated2010-6-21lld:pubmed
pubmed-article:19555158pubmed:abstractTextSphingomyelin-based liposomes were prepared and applied to the stratum corneum side or basal layer side of a three-dimensional (3D) cultured human skin model, and the increase in the type II ceramide (ceramide II) content of the cultured skin model was evaluated. The sphingomyelin-based liposomes were prepared by a high-pressure emulsification method, and the obtained liposomes were characterized; the particle diameter and zeta potential of the liposomes were 155.3 nm and -11.4 mV, respectively. Their spherical shape and lamella structure were observed by transmission electron microscopy. The sphingomyelin-based liposomes or saline were applied to the cultured skin model, and ceramide II was extracted from the skin model. The extracted ceramide II was separated by high-performance thin-layer chromatography and quantified by a densitometer. The amount of ceramide II in the cultured skin model was significantly increased by the application of the sphingomyelin-based liposomes, compared with the nonapplication group. Thus, sphingomyelin-based liposomes are useful for enriching the ceramide level in 3D cultured skin models.lld:pubmed
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pubmed-article:19555158pubmed:authorpubmed-author:HayashiHideno...lld:pubmed
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pubmed-article:19555158pubmed:volume20lld:pubmed
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pubmed-article:19555158pubmed:pagination49-54lld:pubmed
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pubmed-article:19555158pubmed:year2010lld:pubmed
pubmed-article:19555158pubmed:articleTitleEffect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model.lld:pubmed
pubmed-article:19555158pubmed:affiliationFaculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.lld:pubmed
pubmed-article:19555158pubmed:publicationTypeJournal Articlelld:pubmed