pubmed-article:19555158 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0023828 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0007745 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
pubmed-article:19555158 | lifeskim:mentions | umls-concept:C0450363 | lld:lifeskim |
pubmed-article:19555158 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:19555158 | pubmed:dateCreated | 2010-6-21 | lld:pubmed |
pubmed-article:19555158 | pubmed:abstractText | Sphingomyelin-based liposomes were prepared and applied to the stratum corneum side or basal layer side of a three-dimensional (3D) cultured human skin model, and the increase in the type II ceramide (ceramide II) content of the cultured skin model was evaluated. The sphingomyelin-based liposomes were prepared by a high-pressure emulsification method, and the obtained liposomes were characterized; the particle diameter and zeta potential of the liposomes were 155.3 nm and -11.4 mV, respectively. Their spherical shape and lamella structure were observed by transmission electron microscopy. The sphingomyelin-based liposomes or saline were applied to the cultured skin model, and ceramide II was extracted from the skin model. The extracted ceramide II was separated by high-performance thin-layer chromatography and quantified by a densitometer. The amount of ceramide II in the cultured skin model was significantly increased by the application of the sphingomyelin-based liposomes, compared with the nonapplication group. Thus, sphingomyelin-based liposomes are useful for enriching the ceramide level in 3D cultured skin models. | lld:pubmed |
pubmed-article:19555158 | pubmed:language | eng | lld:pubmed |
pubmed-article:19555158 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19555158 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:19555158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19555158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19555158 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:19555158 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:19555158 | pubmed:month | Mar | lld:pubmed |
pubmed-article:19555158 | pubmed:issn | 1532-2394 | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:HayashiHideno... | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:SugibayashiKe... | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:YasudaJunkoJ | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:HashimotoFumi... | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:TodoHiroakiH | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:TokudomeYoshi... | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:HadaNobukoN | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:UchidaRainaR | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:YokoteTakeshi... | lld:pubmed |
pubmed-article:19555158 | pubmed:author | pubmed-author:KonTatsuhikoT | lld:pubmed |
pubmed-article:19555158 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:19555158 | pubmed:volume | 20 | lld:pubmed |
pubmed-article:19555158 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:19555158 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:19555158 | pubmed:pagination | 49-54 | lld:pubmed |
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pubmed-article:19555158 | pubmed:year | 2010 | lld:pubmed |
pubmed-article:19555158 | pubmed:articleTitle | Effect of topically applied sphingomyelin-based liposomes on the ceramide level in a three-dimensional cultured human skin model. | lld:pubmed |
pubmed-article:19555158 | pubmed:affiliation | Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan. | lld:pubmed |
pubmed-article:19555158 | pubmed:publicationType | Journal Article | lld:pubmed |