| pubmed-article:19549869 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0814002 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0152314 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0442038 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0110611 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19549869 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19549869 | pubmed:issue | 27 | lld:pubmed |
| pubmed-article:19549869 | pubmed:dateCreated | 2009-7-8 | lld:pubmed |
| pubmed-article:19549869 | pubmed:abstractText | In the adult dentate gyrus, radial glia-like cells represent putative stem cells generating neurons and glial cells. Here, we combined patch-clamp recordings, biocytin filling, immunohistochemistry, single-cell transcript analysis, and mouse transgenics to test for connexin expression and gap junctional coupling of radial glia-like cells and its impact on neurogenesis. Radial glia-like cells were identified in mice expressing EGFP under control of the nestin and gfap promoters. We show that a majority of Radial glia-like cells are coupled and express Cx43. Neuronal precursors were not coupled. Mice lacking Cx30 and Cx43 in GFAP-positive cells displayed almost complete inhibition of proliferation and a significant decline in numbers of radial glia-like cells and granule neurons. Inducible virus-mediated ablation of connexins in the adult hippocampus also reduced neurogenesis. These findings strongly suggest the requirement of connexin expression by radial glia-like cells for intact neurogenesis in the adult brain and point to possible communication pathways of these cells. | lld:pubmed |
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| pubmed-article:19549869 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19549869 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549869 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19549869 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19549869 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19549869 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:HofmannAndrea... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:TheisMartinM | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:WilleckeKlaus... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:PfeiferAlexan... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:SeifertGerald... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:HüttmannKerst... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:SteinhäuserCh... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:HartmannChris... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:RedeckerChris... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:BednerPeterP | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:KunzeAlbrecht... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:Wallraff-Beck... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:CongresoMarga... | lld:pubmed |
| pubmed-article:19549869 | pubmed:author | pubmed-author:RequardtRober... | lld:pubmed |
| pubmed-article:19549869 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19549869 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:19549869 | pubmed:volume | 106 | lld:pubmed |
| pubmed-article:19549869 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19549869 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19549869 | pubmed:pagination | 11336-41 | lld:pubmed |
| pubmed-article:19549869 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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