| pubmed-article:19549601 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19549601 | lifeskim:mentions | umls-concept:C0033607 | lld:lifeskim |
| pubmed-article:19549601 | lifeskim:mentions | umls-concept:C0908180 | lld:lifeskim |
| pubmed-article:19549601 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:19549601 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19549601 | pubmed:dateCreated | 2009-6-24 | lld:pubmed |
| pubmed-article:19549601 | pubmed:abstractText | Human kallikrein-related peptidase 4 (KLK4/prostase), a trypsin-like serine protease, is a potential target for prostate cancer treatment because of its proteolytic ability to activate many tumorigenic and metastatic pathways including the protease activated receptors (PARs). Currently there are no KLK4-specific small-molecule inhibitors available for therapeutic development. Here we re-engineer the naturally occurring sunflower trypsin inhibitor to selectively block the proteolytic activity of KLK4 and prevent stimulation of PAR activity in a cell-based system. The re-engineered inhibitor was designed using a combination of molecular modeling and sparse matrix substrate screening. | lld:pubmed |
| pubmed-article:19549601 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19549601 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19549601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549601 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19549601 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19549601 | pubmed:issn | 1879-1301 | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:BuckleAshley... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:HarrisJonatha... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:HooperJohn... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:TakayamaThoma... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:ClementsJudit... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:ReidJanet CJC | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:SwedbergJoaki... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:NigonLaura... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:de... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:WalpoleCarina... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:StephensCarso... | lld:pubmed |
| pubmed-article:19549601 | pubmed:author | pubmed-author:WalshTerry... | lld:pubmed |
| pubmed-article:19549601 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19549601 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:19549601 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:19549601 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19549601 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19549601 | pubmed:pagination | 633-43 | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:meshHeading | pubmed-meshheading:19549601... | lld:pubmed |
| pubmed-article:19549601 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19549601 | pubmed:articleTitle | Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. | lld:pubmed |
| pubmed-article:19549601 | pubmed:affiliation | Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland 4059, Australia. | lld:pubmed |
| pubmed-article:19549601 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19549601 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19549601 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19549601 | lld:pubmed |
