| pubmed-article:19549280 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19549280 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:19549280 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:19549280 | lifeskim:mentions | umls-concept:C0052199 | lld:lifeskim |
| pubmed-article:19549280 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:19549280 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:19549280 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:19549280 | pubmed:dateCreated | 2009-8-11 | lld:pubmed |
| pubmed-article:19549280 | pubmed:abstractText | Transforming growth factor-beta1 (TGF-beta1) has central functions in development, tissue maintenance, and repair and has been implicated in major diseases. We discovered that TGF-beta1 contains several amphipathic helices and hydrophobic domains similar to apolipoprotein E (apoE), a protein involved in lipoprotein metabolism. Indeed, TGF-beta1 associates with lipoproteins isolated from human plasma, cultured liver cells, or astrocytes, and its bioactivity was highest in high-density lipoprotein preparations. Importantly, lipoproteins containing the apoE3 isoform had higher TGF-beta levels and bioactivity than those containing apoE4, a major genetic risk factor for atherosclerosis and Alzheimer's disease. Because TGF-beta1 can be protective in these diseases an association with apoE3 may be beneficial. Association of TGF-beta with different types of lipoproteins may facilitate its diffusion, regulate signaling, and offer additional specificity for this important growth factor. | lld:pubmed |
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| pubmed-article:19549280 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19549280 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19549280 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19549280 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19549280 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19549280 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19549280 | pubmed:issn | 1471-4159 | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:ZhangHuiH | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:GongJian-Shen... | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:YanagisawaKat... | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:MichikawaMako... | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:CornJacobJ | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:HuangYadongY | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:Wyss-CorayTon... | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:TesseurInaI | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:WeisgraberKar... | lld:pubmed |
| pubmed-article:19549280 | pubmed:author | pubmed-author:BrechtWalterW | lld:pubmed |
| pubmed-article:19549280 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19549280 | pubmed:volume | 110 | lld:pubmed |
| pubmed-article:19549280 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19549280 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19549280 | pubmed:pagination | 1254-62 | lld:pubmed |
| pubmed-article:19549280 | pubmed:dateRevised | 2010-12-3 | lld:pubmed |
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| pubmed-article:19549280 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19549280 | pubmed:articleTitle | Bioactive TGF-beta can associate with lipoproteins and is enriched in those containing apolipoprotein E3. | lld:pubmed |
| pubmed-article:19549280 | pubmed:affiliation | Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA. | lld:pubmed |
| pubmed-article:19549280 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19549280 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:19549280 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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