| pubmed-article:19545396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19545396 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19545396 | lifeskim:mentions | umls-concept:C0178795 | lld:lifeskim |
| pubmed-article:19545396 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:19545396 | lifeskim:mentions | umls-concept:C1521797 | lld:lifeskim |
| pubmed-article:19545396 | pubmed:dateCreated | 2009-7-29 | lld:pubmed |
| pubmed-article:19545396 | pubmed:abstractText | The purpose was to study the perinatal transmission of human papillomavirus DNA (HPV-DNA) in 63 mother-newborn pairs, besides looking at the epidemiological factors involved in the viral DNA transmission. The following sampling methods were used: (1) in the pregnant woman, when was recruited, in cervix and clinical lesions of the vagina, vulva and perineal region; (2) in the newborn, (a) buccal, axillary and inguinal regions; (b) nasopharyngeal aspirate, and (c) cord blood; (3) in the children, buccal was repeated in the 4th week and 6th and 12th month of life. HPV-DNA was identified using two methodologies: multiplex PCR (PGMY09 and MY11 primers) and nested-PCR (genotypes 6/11, 16, 18, 31, 33, 42, 52 and 58). Perinatal transmission was considered when concordance was found in type-specific HPV between mother/newborn or mother/child. HPV-DNA genital was detected in 49 pregnant women submitted to delivery. Eleven newborns (22.4%, n = 11/49) were HPV-DNA positive. In 8 cases (16.3%, n = 8/49) there was type specific HPV concordance between mother/newborn samples. At the end of the first month of life three children (6.1%, n = 3/49) became HPV-DNA positive, while two remained positive from birth. In 3 cases (100%, n = 3/3) there was type specific HPV concordance between mother/newborn samples. In the 6th month, a child (2%, n = 1/49) had become HPV-DNA positive between the 1st and 6th month of life, and there was type specific HPV concordance of mother/newborn samples. All the HPV-DNA positive children (22.4%, n = 11/49) at birth and at the end first month of life (6.1%, n = 3/49) became HPV-DNA negative at the age of 6 months. The HPV-DNA positive child (2%, n = 1/49) from 1st to the 6th month of life became HPV-DNA negative between the 6th and 12th month of life and one child had anogenital warts. In the twelfth month all (100%, n = 49/49) the children studied were HPV-DNA negative. A positive and significant correlation was observed between perinatal transmission of HPV-DNA and the immunodepression of maternal variables (HIV, p = 0.007). Finally, the study suggests that perinatal transmission of HPV-DNA occurred in 24.5% (n = 12/49) of the cases studied. | lld:pubmed |
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| pubmed-article:19545396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19545396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19545396 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19545396 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19545396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19545396 | pubmed:issn | 1743-422X | lld:pubmed |
| pubmed-article:19545396 | pubmed:author | pubmed-author:MandelliJovan... | lld:pubmed |
| pubmed-article:19545396 | pubmed:author | pubmed-author:SerafiniEduar... | lld:pubmed |
| pubmed-article:19545396 | pubmed:author | pubmed-author:RombaldiRenat... | lld:pubmed |
| pubmed-article:19545396 | pubmed:author | pubmed-author:ZimmermannEdi... | lld:pubmed |
| pubmed-article:19545396 | pubmed:author | pubmed-author:LosquiavoKami... | lld:pubmed |
| pubmed-article:19545396 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19545396 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:19545396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19545396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19545396 | pubmed:pagination | 83 | lld:pubmed |
| pubmed-article:19545396 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:19545396 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19545396 | pubmed:articleTitle | Perinatal transmission of human papilomavirus DNA. | lld:pubmed |
| pubmed-article:19545396 | pubmed:affiliation | Diagnosis - Molecular Laboratory, University of Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil. rl.rombaldi@gmail.com | lld:pubmed |
| pubmed-article:19545396 | pubmed:publicationType | Journal Article | lld:pubmed |
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