| pubmed-article:19538315 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19538315 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:19538315 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:19538315 | lifeskim:mentions | umls-concept:C1521739 | lld:lifeskim |
| pubmed-article:19538315 | lifeskim:mentions | umls-concept:C0173022 | lld:lifeskim |
| pubmed-article:19538315 | pubmed:dateCreated | 2009-6-22 | lld:pubmed |
| pubmed-article:19538315 | pubmed:abstractText | High dietary intake of fruits and vegetables is associated with a reduced disease risk. Therefore, clinical interest is growing in therapies based on dietary supplements and effects of food components. Immune-modulatory and barrier-protective effects have been described for the amino acid glutamine and the trace element zinc. In Caco-2-cells, zinc is necessary to maintain the expression of proteins like ZO-1 and occludin, and experimental evidence exists that glutamine has enterocyte-protective effects and modulates intestinal barrier function in stressed animals and humans. Polyunsaturated fatty acids (PUFA) improve paracellular permeability after IL-4 incubation. Enhancement of barrier properties by long-chain PUFA is discussed controversially, but a beneficial role preventing the redistribution of occludin and ZO-1 and reduction of epithelial resistance by IFN-gamma and TNF-alpha exists. In addition, a group of secondary plant compounds, the polyphenols, are supposed to be important in this respect. The flavonoid quercetin and its metabolite DHBA increased epithelial resistance of Caco-2-cells to 157 +/- 4% of control values, and DHBA up to 119 +/- 4% of control values, respectively. This is due to a 2.3 +/- 0.1-fold expression rate of the tight junction protein claudin-4. | lld:pubmed |
| pubmed-article:19538315 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19538315 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19538315 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19538315 | pubmed:month | May | lld:pubmed |
| pubmed-article:19538315 | pubmed:issn | 1749-6632 | lld:pubmed |
| pubmed-article:19538315 | pubmed:author | pubmed-author:FrommMichaelM | lld:pubmed |
| pubmed-article:19538315 | pubmed:author | pubmed-author:SchulzkeJörg-... | lld:pubmed |
| pubmed-article:19538315 | pubmed:author | pubmed-author:AmashehSalahS | lld:pubmed |
| pubmed-article:19538315 | pubmed:author | pubmed-author:AmashehMarenM | lld:pubmed |
| pubmed-article:19538315 | pubmed:author | pubmed-author:AndresSusanne... | lld:pubmed |
| pubmed-article:19538315 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19538315 | pubmed:volume | 1165 | lld:pubmed |
| pubmed-article:19538315 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19538315 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19538315 | pubmed:pagination | 267-73 | lld:pubmed |
| pubmed-article:19538315 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:meshHeading | pubmed-meshheading:19538315... | lld:pubmed |
| pubmed-article:19538315 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19538315 | pubmed:articleTitle | Barrier effects of nutritional factors. | lld:pubmed |
| pubmed-article:19538315 | pubmed:affiliation | Department of Gastroenterology,Charité, Campus Benjamin Franklin, Berlin, Germany. maren.amasheh@charite.de | lld:pubmed |
| pubmed-article:19538315 | pubmed:publicationType | Journal Article | lld:pubmed |
