| pubmed-article:19535463 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0162340 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0035717 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:19535463 | lifeskim:mentions | umls-concept:C1552861 | lld:lifeskim |
| pubmed-article:19535463 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:19535463 | pubmed:dateCreated | 2009-7-20 | lld:pubmed |
| pubmed-article:19535463 | pubmed:abstractText | More than 130 mutations in human mitochondrial tRNA (mt-tRNA) genes have been correlated with a variety of neurodegenerative and neuromuscular disorders. Their molecular impacts are of mosaic type, affecting various stages of tRNA biogenesis, structure, and/or functions in mt-translation. Knowledge of mammalian mt-tRNA structures per se remains scarce however. Primary and secondary structures deviate from classical tRNAs, while rules for three-dimensional (3D) folding are almost unknown. Here, we take advantage of a myopathy-related mutation A7526G (A9G) in mt-tRNA(Asp) to investigate both the primary molecular impact underlying the pathology and the role of nucleotide 9 in the network of 3D tertiary interactions. Experimental evidence is presented for existence of a 9-12-23 triple in human mt-tRNA(Asp) with a strongly conserved interaction scheme in mammalian mt-tRNAs. Mutation A7526G disrupts the triple interaction and in turn reduces aspartylation efficiency. | lld:pubmed |
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| pubmed-article:19535463 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19535463 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19535463 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19535463 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19535463 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19535463 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19535463 | pubmed:issn | 1469-9001 | lld:pubmed |
| pubmed-article:19535463 | pubmed:author | pubmed-author:FlorentzCathe... | lld:pubmed |
| pubmed-article:19535463 | pubmed:author | pubmed-author:SisslerMarieM | lld:pubmed |
| pubmed-article:19535463 | pubmed:author | pubmed-author:MessmerMarieM | lld:pubmed |
| pubmed-article:19535463 | pubmed:author | pubmed-author:GaudryAgnèsA | lld:pubmed |
| pubmed-article:19535463 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19535463 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:19535463 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19535463 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19535463 | pubmed:pagination | 1462-8 | lld:pubmed |
| pubmed-article:19535463 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:meshHeading | pubmed-meshheading:19535463... | lld:pubmed |
| pubmed-article:19535463 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19535463 | pubmed:articleTitle | Pathology-related mutation A7526G (A9G) helps in the understanding of the 3D structural core of human mitochondrial tRNA(Asp). | lld:pubmed |
| pubmed-article:19535463 | pubmed:publicationType | Letter | lld:pubmed |
| pubmed-article:19535463 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:4555 | entrezgene:pubmed | pubmed-article:19535463 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19535463 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19535463 | lld:pubmed |
