| pubmed-article:19528081 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C1512505 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C1101610 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19528081 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:19528081 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:19528081 | pubmed:dateCreated | 2009-8-11 | lld:pubmed |
| pubmed-article:19528081 | pubmed:abstractText | Estradiol (E2) regulates gene expression at the transcriptional level by functioning as a ligand for estrogen receptor alpha (ERalpha) and estrogen receptor beta (ERbeta). E2-inducible proteins c-Myc and E2Fs are required for optimal ERalpha activity and secondary estrogen responses, respectively. We show that E2 induces 21 microRNAs and represses seven microRNAs in MCF-7 breast cancer cells; these microRNAs have the potential to control 420 E2-regulated and 757 non-E2-regulated mRNAs at the post-transcriptional level. The serine/threonine kinase, AKT, alters E2-regulated expression of microRNAs. E2 induced the expression of eight Let-7 family members, miR-98 and miR-21 microRNAs; these microRNAs reduced the levels of c-Myc and E2F2 proteins. Dicer, a ribonuclease III enzyme required for microRNA processing, is also an E2-inducible gene. Several E2-regulated microRNA genes are associated with ERalpha-binding sites or located in the intragenic region of estrogen-regulated genes. We propose that the clinical course of ERalpha-positive breast cancers is dependent on the balance between E2-regulated tumor-suppressor microRNAs and oncogenic microRNAs. Additionally, our studies reveal a negative-regulatory loop controlling E2 response through microRNAs as well as differences in E2-induced transcriptome and proteome. | lld:pubmed |
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| pubmed-article:19528081 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19528081 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19528081 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:19528081 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19528081 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:19528081 | pubmed:issn | 1362-4962 | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:BrownMylesM | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:SrourEdward... | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:Bhat-Nakshatr... | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:NakshatriHari... | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:CarrollJason... | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:LiuYunlongY | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:WangGuohuaG | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:ThomsonMichae... | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:HammondScottS | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:GeistlingerTi... | lld:pubmed |
| pubmed-article:19528081 | pubmed:author | pubmed-author:CollinsNikail... | lld:pubmed |
| pubmed-article:19528081 | pubmed:issnType | Electronic | lld:pubmed |
