| pubmed-article:19523849 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19523849 | lifeskim:mentions | umls-concept:C0020969 | lld:lifeskim |
| pubmed-article:19523849 | lifeskim:mentions | umls-concept:C0294292 | lld:lifeskim |
| pubmed-article:19523849 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:19523849 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19523849 | pubmed:dateCreated | 2009-6-22 | lld:pubmed |
| pubmed-article:19523849 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19523849 | pubmed:abstractText | Interferons (IFNs) direct innate and acquired immune responses and, accordingly, are used therapeutically to treat a number of diseases, yet the diverse effects they elicit are not fully understood. Here, we identified the promyelocytic leukemia zinc finger (PLZF) protein as a previously unrecognized component of the IFN response. IFN stimulated an association of PLZF with promyelocytic leukemia protein (PML) and histone deacetylase 1 (HDAC1) to induce a decisive subset of IFN-stimulated genes (ISGs). Consequently, PLZF-deficient mice had a specific ISG expression defect and as a result were more susceptible to viral infection. This susceptibility correlated with a marked decrease in the expression of the key antiviral mediators and an impaired IFN-mediated induction of natural killer cell function. These results provide new insights into the regulatory mechanisms of IFN signaling and the induction of innate antiviral immunity. | lld:pubmed |
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| pubmed-article:19523849 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19523849 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19523849 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19523849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19523849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19523849 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19523849 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19523849 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19523849 | pubmed:issn | 1097-4180 | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:WilliamsBryan... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:HigashiyamaSh... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:PandolfiPier... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:LichtJonathan... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:XuDakangD | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:ScottBernadet... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:Berkofsky-Fes... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:HolkoMichelle... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:McConnellMela... | lld:pubmed |
| pubmed-article:19523849 | pubmed:author | pubmed-author:SadlerAnthony... | lld:pubmed |
| pubmed-article:19523849 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19523849 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:19523849 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:19523849 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19523849 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19523849 | pubmed:pagination | 802-16 | lld:pubmed |
| pubmed-article:19523849 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:19523849 | pubmed:meshHeading | pubmed-meshheading:19523849... | lld:pubmed |
| pubmed-article:19523849 | pubmed:meshHeading | pubmed-meshheading:19523849... | lld:pubmed |
