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pubmed-article:19523449pubmed:abstractTextCD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.lld:pubmed
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pubmed-article:19523449pubmed:pagination327-32lld:pubmed
pubmed-article:19523449pubmed:dateRevised2010-11-18lld:pubmed
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pubmed-article:19523449pubmed:articleTitleBlockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells.lld:pubmed
pubmed-article:19523449pubmed:affiliationDepartment of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Tokyo 108-8639, Japan.lld:pubmed
pubmed-article:19523449pubmed:publicationTypeJournal Articlelld:pubmed
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