| pubmed-article:19519589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19519589 | lifeskim:mentions | umls-concept:C0233820 | lld:lifeskim |
| pubmed-article:19519589 | lifeskim:mentions | umls-concept:C0700624 | lld:lifeskim |
| pubmed-article:19519589 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:19519589 | lifeskim:mentions | umls-concept:C1413243 | lld:lifeskim |
| pubmed-article:19519589 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:19519589 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:19519589 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19519589 | pubmed:dateCreated | 2009-6-12 | lld:pubmed |
| pubmed-article:19519589 | pubmed:abstractText | CD86 is a well-known costimulatory molecule in its interaction with CD28 and/or CTLA present on T cells, and is essential for full activation of naïve T-cell and subsequent differentiation. Usually the B7 molecules are expressed mainly on APCs and B cells and in specific conditions on other activated cells. These costimulatory molecules are involved in the development of allergic inflammation and airways hyperreactivity (AHR) in allergen-challenged mice. Activated T cells, CD4(+)CD25(+), express CD86 in the first 60 minutes after the specific inhalatory exposure. These T cells can be relevant in IgE mediated allergic reaction possibly by an autocrine costimulation via CD28/CTLA activation pathway. The blockage of the expression of CD86 could be a potential therapeutical target to reduce the magnitude or the progression of the allergic reaction. The review article also discussed relevant patents. | lld:pubmed |
| pubmed-article:19519589 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19519589 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19519589 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19519589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19519589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19519589 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19519589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19519589 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19519589 | pubmed:issn | 1872-213X | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:HenriquesAnaA | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:PaivaArturA | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:TavaresBeatri... | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:LoureiroGraça... | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:PereiraCelsoC | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:AbrantesMarga... | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:MachadoDaniel... | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:BotelhoFilome... | lld:pubmed |
| pubmed-article:19519589 | pubmed:author | pubmed-author:BaganhaManuel... | lld:pubmed |
| pubmed-article:19519589 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:19519589 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:19519589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19519589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19519589 | pubmed:pagination | 128-31 | lld:pubmed |
| pubmed-article:19519589 | pubmed:dateRevised | 2011-6-17 | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:meshHeading | pubmed-meshheading:19519589... | lld:pubmed |
| pubmed-article:19519589 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19519589 | pubmed:articleTitle | Dynamics of CD86 expression on allergic inflammation--new insights. | lld:pubmed |
| pubmed-article:19519589 | pubmed:affiliation | Immunoallergology Department, Coimbra University Hospital, Portugal. celsopereira.pt@gmail.com | lld:pubmed |
| pubmed-article:19519589 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19519589 | pubmed:publicationType | Review | lld:pubmed |
