| pubmed-article:19507863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C1160466 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C1704711 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:19507863 | lifeskim:mentions | umls-concept:C0248392 | lld:lifeskim |
| pubmed-article:19507863 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:19507863 | pubmed:dateCreated | 2009-7-16 | lld:pubmed |
| pubmed-article:19507863 | pubmed:abstractText | The carbohydrate moieties on conjugating with 3-(1'-hexyloxyethyl)-3-devinyl pyropeophorbide-a (HPPH) altered the uptake and intracellular localization from mitochondria to lysosomes. In vitro, HPPH-Gal 9 PDT showed increased PDT efficacy over HPPH-PDT as detectable by the oxidative cross-linking of nonphosphorylated STAT3 and cell killing in ABCG2-expressing RIF cells but not in ABCG2-negative Colon26 cells. This increased efficacy in RIF cells could at least partially be attributed to increased cellular accumulation of 9, suggesting a role of the ABCG2 transporter for which HPPH is a substrate. While such differences in the accumulation in HPPH derivatives by tumor tissue in vivo were not detectable, 9 still showed an elevated light dose-dependent activity compared to HPPH in mice bearing RIF as well as Colon26 tumors. Further optimization of the carbohydrate conjugates at variable treatment parameters in vivo is currently underway. | lld:pubmed |
| pubmed-article:19507863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19507863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19507863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19507863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19507863 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19507863 | pubmed:issn | 1520-4804 | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:JacksonJennif... | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:BaumannHeinzH | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:PandeySuresh... | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:ChenYihuiY | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:MorganJanetJ | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:BellnierDavid... | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:HendersonBarb... | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:PandeyRavindr... | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:XiangZhengZ | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:MissertJoseph... | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:TracyErinE | lld:pubmed |
| pubmed-article:19507863 | pubmed:author | pubmed-author:BattCarrieC | lld:pubmed |
| pubmed-article:19507863 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19507863 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:19507863 | pubmed:volume | 52 | lld:pubmed |
| pubmed-article:19507863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19507863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19507863 | pubmed:pagination | 4306-18 | lld:pubmed |
| pubmed-article:19507863 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:meshHeading | pubmed-meshheading:19507863... | lld:pubmed |
| pubmed-article:19507863 | pubmed:year | 2009 | lld:pubmed |
