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pubmed-article:19505904pubmed:abstractTextInhibitors of histone deacetylases (HDAC) have shown promise as targeted cancer therapy. Valproate, an older anticonvulsant, has been shown to possess HDAC inhibitory activity. We undertook this case-control study to clarify whether long-term users of valproate had a reduced cancer incidence. If so, it would support HDAC inhibition as a pharmacologic principle in chemoprevention.lld:pubmed
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pubmed-article:19505904pubmed:articleTitleCancer risk in long-term users of valproate: a population-based case-control study.lld:pubmed
pubmed-article:19505904pubmed:affiliationResearch Unit of Clinical Pharmacology, University of Southern Denmark, Odense C, Denmark. jhallas@health.sdu.dklld:pubmed
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