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pubmed-article:19499503pubmed:abstractTextPhytochemical investigation of the aerial parts of Abies chensiensis afforded two new (compounds 2 and 3) and 27 known compounds, including the related compound larixinol ( 1). The structures of spirobiflavonoids 1- 3 were established using 1D and 2D NMR spectroscopic techniques. In addition, the structure of larixinol ( 1) was confirmed by X-ray crystallographic analysis. Compounds 1- 3 were evaluated for inhibitory activities against LPS-induced NO production in macrophages. Larixinol ( 1) showed moderate effects, with an IC(50) value of 60.0 microg/mL. In addition, it did not show any cytotoxicity on RAW 264.7 macrophages at 100 microg/mL.lld:pubmed
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pubmed-article:19499503pubmed:authorpubmed-author:TangJianJlld:pubmed
pubmed-article:19499503pubmed:authorpubmed-author:ZhangWei-Dong...lld:pubmed
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pubmed-article:19499503pubmed:authorpubmed-author:TianJun-MianJ...lld:pubmed
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pubmed-article:19499503pubmed:authorpubmed-author:HuangDa-SengD...lld:pubmed
pubmed-article:19499503pubmed:copyrightInfoGeorg Thieme Verlag KG Stuttgart, New York.lld:pubmed
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pubmed-article:19499503pubmed:volume75lld:pubmed
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pubmed-article:19499503pubmed:year2009lld:pubmed
pubmed-article:19499503pubmed:articleTitleTwo new spirobiflavonoids from Abies chensiensis with moderate NO production inhibitory activity.lld:pubmed
pubmed-article:19499503pubmed:affiliationDepartment of Natural Product Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.lld:pubmed
pubmed-article:19499503pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:19499503pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed