| pubmed-article:19497297 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0041348 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0243071 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C1998793 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0205431 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0205352 | lld:lifeskim |
| pubmed-article:19497297 | lifeskim:mentions | umls-concept:C0073172 | lld:lifeskim |
| pubmed-article:19497297 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:19497297 | pubmed:dateCreated | 2009-7-14 | lld:pubmed |
| pubmed-article:19497297 | pubmed:abstractText | (-)-Rhazinilam was spontaneously generated from a natural product during isolation. In cultured cells, it causes microtubule bundle formation, like those caused by paclitaxel. With tubulin, (-)-rhazinilam causes formation of an aberrant spiral polymer. Using glutamate and GTP, we developed an assay for spiral formation and applied it to 17 new (+/-)-rhazinilam analogs with either a modified side chain or a different size D ring. There was reasonable correlation between spiral formation and inhibition of human MCF-7 breast carcinoma cell growth. Only one side chain analog was as active as (+/-)-rhazinilam. During these studies, we observed that omitting GTP from the reaction mixture caused a major change in the morphology of the (-)-rhazinilam-induced polymer, with half the observed polymer being microtubule-like and half being spirals. This mixed polymer slowly disassembled at 0 degrees C, but there was no apparent difference in the lability of the microtubules versus the spirals. | lld:pubmed |
| pubmed-article:19497297 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19497297 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19497297 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19497297 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:19497297 | pubmed:issn | 1096-0384 | lld:pubmed |
| pubmed-article:19497297 | pubmed:author | pubmed-author:BornmannWilli... | lld:pubmed |
| pubmed-article:19497297 | pubmed:author | pubmed-author:EdlerMichael... | lld:pubmed |
| pubmed-article:19497297 | pubmed:author | pubmed-author:HamelErnestE | lld:pubmed |
| pubmed-article:19497297 | pubmed:author | pubmed-author:BaiRuoliR | lld:pubmed |
| pubmed-article:19497297 | pubmed:author | pubmed-author:YangGuangliG | lld:pubmed |
| pubmed-article:19497297 | pubmed:author | pubmed-author:Katherine... | lld:pubmed |
| pubmed-article:19497297 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19497297 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:19497297 | pubmed:volume | 487 | lld:pubmed |
| pubmed-article:19497297 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19497297 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19497297 | pubmed:pagination | 98-104 | lld:pubmed |
| pubmed-article:19497297 | pubmed:dateRevised | 2011-9-28 | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:meshHeading | pubmed-meshheading:19497297... | lld:pubmed |
| pubmed-article:19497297 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19497297 | pubmed:articleTitle | Demonstration of microtubule-like structures formed with (-)-rhazinilam from purified tubulin outside of cells and a simple tubulin-based assay for evaluation of analog activity. | lld:pubmed |
| pubmed-article:19497297 | pubmed:affiliation | Toxicology and Pharmacology Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD 21702, USA. | lld:pubmed |
| pubmed-article:19497297 | pubmed:publicationType | Journal Article | lld:pubmed |
