| pubmed-article:19481338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C0001483 | lld:lifeskim |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C0346647 | lld:lifeskim |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C1140618 | lld:lifeskim |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C1413583 | lld:lifeskim |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19481338 | lifeskim:mentions | umls-concept:C1518581 | lld:lifeskim |
| pubmed-article:19481338 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19481338 | pubmed:dateCreated | 2009-9-28 | lld:pubmed |
| pubmed-article:19481338 | pubmed:abstractText | Conditionally-replicating adenovirus (CRAd) therapy is currently being tested against pancreatic cancer and has shown some promise. To improve the efficacy, a novel virus CRAd-Cans was designed by deletion of E1B-55kDa gene for selective replication in tumor cells, as well as carrying a new angiogenesis inhibitor gene, canstatin. CRAd-Cans mediated higher expression of canstatin in BxPC-3 pancreatic cancer cell line compared to the replication-deficient adenovirus Ad5-Cans. The modified CRAd-Cans manifested the same selective replication and cytocidal effects in pancreatic cancer cells as ONYX-015 in vitro, yet showed greater reduction of tumor growth in nude mice with markedly prolonged survival rate in vivo (P<0.05), compared to that of either ONYX-015 or Ad5-Cans. Pathological examination revealed viral replication, decreased microvessel density and increased cancer cell apoptosis in CRAd-Cans-treated xenografts. The results suggest that the novel oncolytic virus CRAd-Cans, showing synergistic effects of oncolytic therapy and anti-angiogenesis therapy, is a new promising therapeutics for pancreatic cancer. | lld:pubmed |
| pubmed-article:19481338 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19481338 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481338 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19481338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19481338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19481338 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:19481338 | pubmed:issn | 1872-7980 | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:CoxS GSG | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:JinJingJ | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:LiHong-DaHD | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:HeXiao-PingXP | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:PanXueX | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:LiZhao-ShenZS | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:TuZhen-XingZX | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:WangXing-HuaX... | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:ManXiao-HuaXH | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:SuChang-QingC... | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:LiaoZhuanZ | lld:pubmed |
| pubmed-article:19481338 | pubmed:author | pubmed-author:GongYang-Fang... | lld:pubmed |
| pubmed-article:19481338 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19481338 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:19481338 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:19481338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19481338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19481338 | pubmed:pagination | 89-98 | lld:pubmed |
| pubmed-article:19481338 | pubmed:dateRevised | 2010-5-20 | lld:pubmed |
| pubmed-article:19481338 | pubmed:meshHeading | pubmed-meshheading:19481338... | lld:pubmed |
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| pubmed-article:19481338 | pubmed:meshHeading | pubmed-meshheading:19481338... | lld:pubmed |
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| pubmed-article:19481338 | pubmed:meshHeading | pubmed-meshheading:19481338... | lld:pubmed |
| pubmed-article:19481338 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19481338 | pubmed:articleTitle | E1B-55kD-deleted oncolytic adenovirus armed with canstatin gene yields an enhanced anti-tumor efficacy on pancreatic cancer. | lld:pubmed |
| pubmed-article:19481338 | pubmed:affiliation | Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China. | lld:pubmed |
| pubmed-article:19481338 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19481338 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:1284 | entrezgene:pubmed | pubmed-article:19481338 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:19481338 | lld:entrezgene |
