| pubmed-article:194763 | pubmed:otherAbstract | PIP: A 50-year-old woman with serious rheumatism was effectively treated with a combination administration of high doses of estrogens. Presomen (1st-12th day, 3 times daily at 1.25 mg, 13th-23rd day 0.6 mg) and Primosiston (13th-23rd day, 1 tablet 3 times daily) were used. It was inquired as to whether in regard to this particular hormonal substitution there was a contraindication due to the risk of genital carcinoma, and how long such a treatment could be safely undertaken. In response, the author, on the basis of his own clinical experience, considers that conjugated doses of estrogens are generally well taken. The 1.25 mg of Presomen in the first 12 days is considered to be rather high. The risks which are to be seriously considered through the administration of these type or preparations in women during this period are thromboembolism (adiposia, hyperlipidemia, nicotine abuse, operations, and immoblizations being the primary backgrounds). From time to time examinations must be undertaken and the dosage of estrogens reduced. | lld:pubmed |
