| pubmed-article:1945831 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1945831 | lifeskim:mentions | umls-concept:C0087140 | lld:lifeskim |
| pubmed-article:1945831 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:1945831 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:1945831 | lifeskim:mentions | umls-concept:C0220905 | lld:lifeskim |
| pubmed-article:1945831 | lifeskim:mentions | umls-concept:C1705241 | lld:lifeskim |
| pubmed-article:1945831 | lifeskim:mentions | umls-concept:C1705242 | lld:lifeskim |
| pubmed-article:1945831 | pubmed:issue | 20 | lld:pubmed |
| pubmed-article:1945831 | pubmed:dateCreated | 1991-12-2 | lld:pubmed |
| pubmed-article:1945831 | pubmed:abstractText | Fra-2, one of the Fos-related antigens, is promptly expressed after the growth stimulation of fibroblasts, but its induction peak is later than that of c-Fos. In this report, we examined biochemical properties of Fra-2 and compared them with those of two other Fos family proteins, c-Fos and Fra-1. Like c-Fos and Fra-1, Fra-2 formed stable heterodimers with c-Jun, JunB or JunD in vitro and all these complexes had specific DNA-binding activity to AP-1-binding sites (AP-1 sites) or related sequences. When transiently introduced into a mouse embryonic carcinoma cell line, F9, with reporter genes containing the AP-1 site from the collagenase gene, fra-2 plus c-jun suppressed the transactivation by c-jun alone. This property of Fra-2 is in clear contrast to that of c-Fos, which stimulates the transcriptional activity of c-Jun by forming a stable heterodimer. Analysis of chimeric proteins between c-Fos and Fra-2 indicated that this difference is mainly attributable to their C terminal-half regions. Interestingly, this suppressive effect of Fra-2 was not observed in the combination with JunD: fra-2 plus junD, like c-fos plus junD, had higher transcriptional activity than junD alone. Fra-1 showed essentially the same transcriptional regulatory properties as Fra-2. These differential properties greatly expand the potential range of regulatory functions of the Fos family proteins. | lld:pubmed |
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| pubmed-article:1945831 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1945831 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1945831 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1945831 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1945831 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:1945831 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:1945831 | pubmed:author | pubmed-author:SuzukiTT | lld:pubmed |
| pubmed-article:1945831 | pubmed:author | pubmed-author:EndoTT | lld:pubmed |
| pubmed-article:1945831 | pubmed:author | pubmed-author:YoshidaTT | lld:pubmed |
| pubmed-article:1945831 | pubmed:author | pubmed-author:OkunoHH | lld:pubmed |
| pubmed-article:1945831 | pubmed:author | pubmed-author:IbaHH | lld:pubmed |
| pubmed-article:1945831 | pubmed:author | pubmed-author:NishineTT | lld:pubmed |
| pubmed-article:1945831 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1945831 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:1945831 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:1945831 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1945831 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1945831 | pubmed:pagination | 5537-42 | lld:pubmed |
| pubmed-article:1945831 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1945831 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1945831 | pubmed:articleTitle | Difference in transcriptional regulatory function between c-Fos and Fra-2. | lld:pubmed |
| pubmed-article:1945831 | pubmed:affiliation | Department of Tumor Virus Research, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:1945831 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1945831 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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