| pubmed-article:19451693 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C0033325 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C1819426 | lld:lifeskim |
| pubmed-article:19451693 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:19451693 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19451693 | pubmed:dateCreated | 2009-6-2 | lld:pubmed |
| pubmed-article:19451693 | pubmed:abstractText | In human breast cancer, loss of carcinoma cell-specific response to TGF-beta signaling has been linked to poor patient prognosis. However, the mechanisms through which TGF-beta regulates these processes remain largely unknown. In an effort to address this issue, we have now identified gene expression signatures associated with the TGF-beta signaling pathway in human mammary carcinoma cells. The results strongly suggest that TGF-beta signaling mediates intrinsic, stromal-epithelial, and host-tumor interactions during breast cancer progression, at least in part, by regulating basal and oncostatin M-induced CXCL1, CXCL5, and CCL20 chemokine expression. To determine the clinical relevance of our results, we queried our TGF-beta-associated gene expression signatures in 4 human breast cancer data sets containing a total of 1,319 gene expression profiles and associated clinical outcome data. The signature representing complete abrogation of TGF-beta signaling correlated with reduced relapse-free survival in all patients; however, the strongest association was observed in patients with estrogen receptor-positive (ER-positive) tumors, specifically within the luminal A subtype. Together, the results suggest that assessment of TGF-beta signaling pathway status may further stratify the prognosis of ER-positive patients and provide novel therapeutic approaches in the management of breast cancer. | lld:pubmed |
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| pubmed-article:19451693 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19451693 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19451693 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:19451693 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19451693 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19451693 | pubmed:issn | 1558-8238 | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:ChengNikkiN | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:ShyrYuY | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:ChytilAnnaA | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:MosesHarold... | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:ParkerJoel... | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:BierieBrianB | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:ChungChristin... | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:AakreMaryM | lld:pubmed |
| pubmed-article:19451693 | pubmed:author | pubmed-author:StoverDaniel... | lld:pubmed |
| pubmed-article:19451693 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19451693 | pubmed:volume | 119 | lld:pubmed |
| pubmed-article:19451693 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19451693 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19451693 | pubmed:pagination | 1571-82 | lld:pubmed |
| pubmed-article:19451693 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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