| pubmed-article:19450444 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19450444 | lifeskim:mentions | umls-concept:C0085156 | lld:lifeskim |
| pubmed-article:19450444 | lifeskim:mentions | umls-concept:C0521119 | lld:lifeskim |
| pubmed-article:19450444 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:19450444 | lifeskim:mentions | umls-concept:C1260959 | lld:lifeskim |
| pubmed-article:19450444 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:19450444 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:19450444 | pubmed:dateCreated | 2009-5-21 | lld:pubmed |
| pubmed-article:19450444 | pubmed:abstractText | Human retinal pigment epithelial (RPE) cells synthesize an extraneous splice isoform of retinal G protein-coupled receptor (RGR). In this study, we analyzed the exon-skipping variant of RGR (RGR-d) that is found in extracellular deposits. RPE-choroid tissue sections were prepared from postmortem human eyes from donors of various ages. RGR-d was analyzed in drusen and Bruch's membrane by immunohistochemical localization. Extracellular RGR-d is present in most drusen, including hard, soft, confluent and early-stage. Initial drusen formation is known to be preferentially associated with the intercapillary regions of Bruch's membrane. We corroborated this significant association of drusen, including early-stage drusen, with the intercapillary regions. The distribution of extracellular RGR-d in Bruch's membrane differs in old and young donors. In older persons, nodes of concentrated RGR-d accumulate at intercapillary loci, predominantly at the lateral edges of the capillaries of the choriocapillaris. RGR-d loci at the lateral capillary wall appear numerous in old, but not young, donors. Intensely immunostained RGR-d loci can be found at the base of early-stage drusen mounds in the older donors and may precede the formation of these drusen. | lld:pubmed |
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| pubmed-article:19450444 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19450444 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19450444 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19450444 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:19450444 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19450444 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:19450444 | pubmed:issn | 1096-0007 | lld:pubmed |
| pubmed-article:19450444 | pubmed:author | pubmed-author:FongHenry K... | lld:pubmed |
| pubmed-article:19450444 | pubmed:author | pubmed-author:JohnsonLincol... | lld:pubmed |
| pubmed-article:19450444 | pubmed:author | pubmed-author:KochounianHar... | lld:pubmed |
| pubmed-article:19450444 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19450444 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:19450444 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19450444 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19450444 | pubmed:pagination | 1129-36 | lld:pubmed |
| pubmed-article:19450444 | pubmed:dateRevised | 2010-9-27 | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:meshHeading | pubmed-meshheading:19450444... | lld:pubmed |
| pubmed-article:19450444 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19450444 | pubmed:articleTitle | Accumulation of extracellular RGR-d in Bruch's membrane and close association with drusen at intercapillary regions. | lld:pubmed |
| pubmed-article:19450444 | pubmed:affiliation | Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. | lld:pubmed |
| pubmed-article:19450444 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19450444 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
